Evidence map›Paper›PMID 42576614›Full record

ArticleJournal of cellular and molecular medicine2026

RAS Inhibitor RMC-7977 Blocks Vascular Overgrowth of NRAS

Sara Alharbi, Svatava Merkle, Patricia Pastura, C Griffin McDaniel, George S Zaky, Andrew M Waters, Timothy D Le Cras

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara AlharbiDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-4477-9592
Svatava MerkleDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0001-7604-3849
Patricia PasturaDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
C Griffin McDanielDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-0573-0956
George S ZakyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0009-0003-3088-218X
Andrew M WatersDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-6058-5878
Timothy D Le CrasDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0001-8538-2703

Funding

Pathogenesis and Treatment of Kaposiform LymphangiomatosisR01HL156866 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TIMOTHY DAVID LE CRAS · 2022 to 2026
$3.3M
Lymphatic Malformation InstituteNational Institutes of Health HL156866NHLBI NIH HHS R01 HL156866
6 · The paper itself

Abstract

RAS mutations occur in patients with several types of vascular anomalies, but effective treatments remain limited. To address this need, we evaluated the RAS (ON) multi-selective inhibitor RMC-7977 in human endothelial cells (ECs) expressing the NRAS

Indexed as

Endothelial CellsGTP PhosphohydrolasesMembrane ProteinsMutationNeovascularization, Pathologicras ProteinsAngiogenesisAngiopoietin-2AnimalsCell MovementCell ProliferationHemangioendotheliomaHumansKasabach-Merritt SyndromeMiceMice, NudeAngiopoietin-2GTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanPiperazinesras ProteinsRMC-7977complex lymphatic malformationHRASkaposiform lymphangiomatosisKRASNRASvascular anomalies

Identifiers

PMID42576614
PMCPMC13458280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.