Evidence map›Paper›PMID 42576611›Full record

ArticleThe Plant journal : for cell and molecular biology2026

The transcription factor ZmMYB3R targets CYCB1;2 to modulate maize drought tolerance.

Kang Guo, Yingli Jiang, Yuxin Guo, Jingtao Li, Li Cheng, Changyou Yu, Yun Yang, Xiaoyu Li, Chengyun Wu, Jiandong Wu

Abstract read
In one paragraph

Article in The Plant journal : for cell and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Kang Guo *The National Engineering Lab of Crop Stress Resistance Breeding, School of Agronomy, Anhui Agricultural University, Hefei, 230036, China.
Yingli Jiang *The National Engineering Lab of Crop Stress Resistance Breeding, School of Agronomy, Anhui Agricultural University, Hefei, 230036, China.
Yuxin Guo *The National Engineering Lab of Crop Stress Resistance Breeding, School of Agronomy, Anhui Agricultural University, Hefei, 230036, China.
Jingtao LiSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, China.
Li ChengSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, China.
Changyou YuSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, China.
Yun YangSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, China.
Xiaoyu LiThe National Engineering Lab of Crop Stress Resistance Breeding, School of Agronomy, Anhui Agricultural University, Hefei, 230036, China.
Chengyun WuThe National Engineering Lab of Crop Stress Resistance Breeding, School of Agronomy, Anhui Agricultural University, Hefei, 230036, China.ORCID https://orcid.org/0000-0002-8202-5134
Jiandong WuThe National Engineering Lab of Crop Stress Resistance Breeding, School of Agronomy, Anhui Agricultural University, Hefei, 230036, China.ORCID https://orcid.org/0000-0002-0739-2479

Funding

Anhui Provincial Natural Science Foundation 2408085MC057Anhui Provincial Natural Science Foundation 2508085Y016Key Science & Technology Project of Anhui Province 202423l10050038Key Scientific Research Project of Colleges and Universities in Henan Province 24A180006National Key R&D Program of China 2021YFF1000304National Natural Science Foundation of China 32372019National Natural Science Foundation of China 32472043National Natural Science Foundation of China 32501834Program for High-level Talents Recruitment of Anhui Agricultural University rc422305University Outstanding Young Teachers Cultivation Program of the Department of Education of Anhui Province YQZD2025011
6 · The paper itself

Abstract

The R1R2R3-MYB (3R-MYB) transcription factor subfamily is associated with stress tolerance; however, the underlying mechanisms in crops remain poorly understood. This study investigates the function of maize MYB3R in regulating seedling drought tolerance. We characterised MYB3R overexpression lines and CRISPR-Cas9 loss-of-function mutants in maize and rice using physiological assays and transcriptome profiling. DNA affinity purification sequencing (DAP-seq) and molecular interaction assays were employed to identify direct downstream targets. MYB3R overexpression enhanced drought tolerance by promoting root development, stomatal closure and antioxidant defence, whereas mutants displayed hypersensitivity. MYB3R binds the mitosis-specific activator (MSA) motif to directly transactivate the B-type cyclin gene CYCB1;2, and cycb1;2 mutants phenocopied the myb3r drought defects. These findings establish that the MYB3R-CYCB1;2 module positively regulates maize drought tolerance by coordinating developmental and physiological adaptations. This pathway provides a valuable molecular target for breeding drought-resilient crops.

Indexed as

Plant ProteinsTranscription FactorsZea maysDrought ResistanceDroughtsGene Expression Regulation, PlantOryzaPlant RootsPlants, Genetically ModifiedPlant StomataSeedlingsStress, PhysiologicalPlant ProteinsTranscription Factorsantioxidant defenceCYCB1;2drought toleranceMYB3Rroot developmentstomata

Identifiers

PMID42576611
PMCPMC13458425

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.