Evidence map›Paper›PMID 42576545›Full record

ArticleTransboundary and emerging diseases2026

Genomic Characterization of an Emergent Cross-Border Recombinant Duck Plague Virus With High Pathogenicity and Reduced Vaccine Efficacy in Guangxi, China.

Songlin Yang, Shijun Xu, Kairu Wang, Chao Liu, Hongchun Yang, Liuyang Yuan, Shuangshuang Ma, Huayan Xie, Zhimin Zhang, Gonghe Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Songlin YangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.ORCID https://orcid.org/0009-0002-4666-012X
Shijun XuCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.ORCID https://orcid.org/0009-0006-5588-4116
Kairu WangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.ORCID https://orcid.org/0009-0008-8180-2668
Chao LiuQilu Animal Health Products Co. Ltd, Jinan 250100, China.ORCID https://orcid.org/0009-0004-8662-8516
Hongchun YangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.
Liuyang YuanCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.
Shuangshuang MaCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.
Huayan XieCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.
Zhimin ZhangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.
Gonghe LiCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.ORCID https://orcid.org/0009-0003-0150-8818
Hongbin SiCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.
Kun NingMedical Laboratory Animal Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, tjutcm.edu.cn.ORCID https://orcid.org/0009-0007-0211-6030
Changbo OuCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China, gxu.edu.cn.ORCID https://orcid.org/0000-0001-9912-5740

Funding

Guangxi Agriculture Research System Innovation Team nycytxgxcxtd-2024-19
6 · The paper itself

Abstract

Duck plague virus (DPV) is a major pathogen causing recurrent outbreaks in waterfowl. This study reports the comprehensive characterization of a novel DPV strain, designated GXGG240520, isolated from clinically diseased ducks in Guangxi, China. The strain was confirmed as a virulent DPV by PCR targeting the UL2 gene (1002 bp) and exclusion of other common duck pathogens. In pathogenicity tests, ducks challenged with GXGG240520 exhibited severe clinical signs including anorexia, diarrhea, and hemorrhagic stools, with mortality concentrated between 5 and 9 days postchallenge and a final survival rate of only 10%. Pathological examination revealed hemorrhagic lesions in multiple organs and atrophy of immune organs such as the bursa of Fabricius and thymus. Viral load was highest in the thymus and lowest in the heart. Notably, challenge protection experiments demonstrated that the currently available vaccine (C-KCE strain) provided only limited protection, with 60% mortality in vaccinated ducks, indicating reduced vaccine efficacy capability. Whole-genome sequencing revealed a genome length of 162,188 bp with 78 predicted open reading frames (ORFs). Comparative genomic analysis identified 40 amino acid deletions and mutations across 26 ORFs. Homologous recombination analysis confirmed that GXGG240520 originated from cross-border recombination between the Chinese virulent strain CHv (major parent) and the Bangladeshi strain YLBRDP 11 (minor parent). Furthermore, structure prediction of the UL47 protein revealed marked differences in α-helix and β-sheet organization compared to both parental strains. This recombinant strain with high pathogenicity and reduced vaccine efficacy potential poses a significant challenge to current DPV control strategies.

Indexed as

DucksGenome, ViralMardivirusMarek DiseasePoultry DiseasesViral VaccinesAnimalsChinaPhylogenyVirulenceViral Vaccinesduck plague viruspathogenicitywhole genome sequencing

Identifiers

PMID42576545
PMCPMC13458276

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.