Evidence map›Paper›PMID 42576500›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[Prognostic value of palmitoyl-protein thioesterase-1 in gastric cancer and its regulatory role in tumor cell lipid metabolism].

Bingyi Huang, Yujie Gao, Jingyi Xie, Chen Yan, Mengru Gu, Zhizhi Zhang, Jintao Guo, Song Liu, Ziliang Wang, Yuping Yang and 2 more

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bingyi HuangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Yujie GaoDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Jingyi XieDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Chen YanAnhui Provincial Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Mengru GuAnhui Provincial Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Zhizhi ZhangAnhui Provincial Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Jintao GuoDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Song LiuDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Ziliang WangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Yuping YangBengbu Hospital of Comprehensive Regional Medical Center (Second Affiliated Hospital of Bengbu Medical University), Bengbu 233004, China.
Lugen ZuoDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Deli ChenDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate palmitoyl-protein thioesterase-1 (PPT1) expression in gastric cancer (GC), its prognostic significance, and its regulatory role in tumor cell lipid metabolism.

methodsPPT1 expression was analyzed using TCGA-STAD data and immunohistochemistry of clinical samples. In a retrospective cohort of 136 GC patients undergoing radical resection, the association between PPT1 and 5-year survival was evaluated using Kaplan-Meier and Cox regression analyses, and a nomogram was constructed and validated by ROC analysis. GO and REACTOME enrichment analyses were conducted to identify the pathways involved. In cultured GC cell lines with PPT1 knockdown or overexpression, the changes in cell proliferation, migration and invasion were assessed using CCK-8 and Transwell assays. Oil Red O staining, Western blotting and U0126 rescue experiments were performed to explore the role of PPT1-mediated ERK signaling in tumor cell lipid metabolism.

resultsPPT1 protein, localized in the cytoplasm, was significantly upregulated in GC tissues compared with adjacent normal tissues. High PPT1 expression was closely correlated with elevated serum CEA and CA19-9 levels and advanced T and N stages (

conclusionsPPT1 is overexpressed in GC tissues and predicts poor prognosis. PPT1 overexpression promotes GC progression by activating the ERK signaling pathway and thereby modulating lipid metabolism, suggesting its potential as a novel prognostic biomarker and a therapeutic target for GC.

Indexed as

Lipid MetabolismStomach NeoplasmsThiolester HydrolasesCell Line, TumorCell MovementCell ProliferationFemaleHumansMAP Kinase Signaling SystemPrognosisRetrospective Studiespalmitoyl-protein thioesteraseThiolester Hydrolasesgastric cancerlipid metabolismMAPK signaling pathwaymigration and invasionpalmitoyl-protein thioesterase-1poor prognosisproliferation

Identifiers

PMID42576500
PMCPMC13458736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.