Evidence map›Paper›PMID 42576496›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[MiR-124 ameliorates MK-801-induced anxiety-like behaviors in mice by promoting hippocampal neural stem cell proliferation and differentiation].

Dongkun Yu, Shijie Zhi, Yanbo Liu, Zhilun Yang, Juan Liu, Yu Shao

Abstract readEnglish Abstract
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dongkun YuSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.
Shijie ZhiSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.
Yanbo LiuSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.
Zhilun YangSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.
Juan LiuGeneral Hospital of Ningxia Medical University, Yinchuan 750004, China.
Yu ShaoSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the regulatory effect of miR-124 on MK-801-induced anxiety-like behavior in mice.

methodsSixty 6-week-old male C57BL/6J mice were randomly divided into control group, MK-801+Saline group, MK-801+Vehicle group, and MK-801+miR-124 group (

resultsThe mice in MK-801+miR-124 group showed significantly increased hippocampal miR-124 levels after the injection. The mice receiving miR-124 microinjection exhibited significant increases in both the total and central zone distance traveled in open field test and in percentages of time spent in the open arms in elevated plus maze test. Hippocampal Tuj1 protein expression and the numbers of hippocampal neural stem cells and newborn neurons, along with the fluorescence area ratio of newborn to mature neurons, increased significantly in the mice in MK-801+miR-124 group.

Indexed as

AnxietyCell DifferentiationHippocampusMicroRNAsNeural Stem CellsAnimalsCell ProliferationDizocilpine MaleateMaleMiceMice, Inbred C57BLDizocilpine MaleateMicroRNAsMirn124 microRNA, mouseanxietymiR-124neural stem cellsneurons

Identifiers

PMID42576496
PMCPMC13458367

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.