ArticleCNS neuroscience & therapeutics2026
Topographical Patterns of Intraventricular Hemorrhage as a Novel Prognostic Imaging Biomarker in Intracerebral Hemorrhage.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Development and Internal Validation of an Inflammatory-Coagulation Biomarker-Enhanced Nomogram for 90-Day Outcome After Deep Hypertension-Related Intracerebral Hemorrhage.Neuropsychiatric disease and treatment · 2026Article
- Inflammatory burden index is associated with poor functional outcome and stroke-associated pneumonia in patients with primary brainstem hemorrhage: a retrospective cohort study.Frontiers in neuroscience · 2026Article
- The predictive value of the leuko-glycemic index in spontaneous intracerebral hemorrhage patients undergoing neurosurgical operation: a retrospective cohort study.Frontiers in neurology · 2026Article
- Hematoma expansion in intracerebral hemorrhage: neuroimaging biomarkers, radiomics-based prediction models, and clinical translation.Frontiers in human neuroscience · 2026Review
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6 authors.
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Abstract
aimsCurrent intraventricular hemorrhage (IVH) scoring systems quantify individual hemorrhage site features but do not account for differences in overall IVH distribution. We aimed to develop a scoring system based on overall IVH topographical patterns, and evaluate its value for predicting outcomes in intracerebral hemorrhage (ICH).
methodsWe conducted a retrospective analysis of a database including 385 patients with spontaneous ICH, IVH, and hematoma volumes < 40 mL between June 2019 and October 2024. We identified independent predictors of 30-day mortality, evaluated whether IVH spatial features could replace existing IVH scores, developed a novel IVH topographical score (ITS) scoring system, and compared it with four established scoring systems.
resultsThe IVH topographical patterns demonstrated significantly superior predictive performance for mortality compared with the original and modified Graeb scores. Multivariate analysis identified IVH topographical patterns, hydrocephalus, hematoma volume, and Glasgow Coma Scale score as independent predictors. The ITS demonstrated superior predictive performance for 30-day mortality compared with the other four, including in the external validation cohort (n = 102), while its performance for 6-month outcomes was comparable to the other four.
conclusionTopographical patterns of IVH provide an intuitive tool for risk stratification in patients with IVH. However, larger prospective studies are warranted to validate these findings in broader populations.
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