ArticleRapid communications in mass spectrometry : RCM2026
Dopant-Assisted APCI for Enhanced Sugar Analysis: Overcoming Ionization Bottlenecks.
Article in Rapid communications in mass spectrometry : RCM, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
rationaleThe investigation of lignocellulosic biomass by atmospheric-pressure chemical ionization (APCI) mass spectrometry (MS) has revealed significant issues for carbohydrate ionization, particularly during biomass pyrolysis analyses. Unequal ionization of carbohydrates and significant fragmentation have been reported. The introduction of suitable dopants into the ion source shows promise for limiting fragmentation.
methodsTo investigate these ionization disturbances, both direct infusion (DI) and modified direct insertion probe (DIP) APCI coupled with a Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS) were employed. Solvents with increasing proton affinity (PA) were used to assess solvent PA influence in DI-APCI ionization processes. The DIP system was modified to enable the introduction of an inert gas stream passing through a dopant-rich atmosphere prior to entering the ion source.
resultsA significant PA difference between the solvent and the analyte promotes carbohydrate dissociation after their ionization. Experiments without solvent and with deuterated compounds showed that carbohydrate ionization and dissociation may be self-induced by water formed during carbohydrate dehydration. The introduction of ammonia in the ion source promoted the [M + NH
conclusionsThe dopant-assisted APCI (dAPCI) approach appears highly promising for the rapid assessment of biomass fast pyrolysis, particularly when highly oxygenated compounds are key markers. Careful selection of dopants and solvents is essential in carbohydrate analysis to preserve analyte structural integrity during ionization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.