Evidence map›Paper›PMID 42576411›Full record

ReviewExperimental dermatology2026

Antimicrobial Peptides of the Skin: Roles in Skin Cancer and Clinical Applications.

Elizabeth Botto, Zoe M Lipman, Laurie A Temiz, Lilia Corea-Selm, James M Grichnik

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Elizabeth BottoMorsani College of Medicine, University of South Florida, Tampa, Florida, USA.ORCID https://orcid.org/0000-0003-4461-1965
Zoe M LipmanDepartment of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, Florida, USA.
Laurie A TemizDepartment of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, Florida, USA.
Lilia Corea-SelmDepartment of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-6289-0465
James M GrichnikDepartment of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, Florida, USA.ORCID https://orcid.org/0000-0002-9185-0056

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous antimicrobial peptides (AMPs) are increasingly recognized for their multifaceted roles in skin disease and cancer, and thus application for therapeutic potential. Beyond their contributions to innate defence and the skin's microbiome, AMPs have been implicated in inflammatory skin conditions and cutaneous malignancies. Comprehensive summaries of AMPs' roles in skin cancer and related current clinical developments remain scarce, despite abundant emerging evidence of pro- and anti-tumour properties in other fields. This review provides a comprehensive discussion of AMPs, including dermcidin, psoriasin (S100A7), human cathelicidin (LL-37), RNase-7 and the human β-defensins, in the context of skin cancer research and clinical developments. These AMPs influence skin tumorigenesis through microbiome regulation, innate immune pathways and chronic inflammation, and although the mechanistic details are subject to scrutiny, several AMP-derived therapies, including LL-37 and LTX-315, have been developed for their potential in cutaneous oncology.

Indexed as

Antimicrobial Cationic PeptidesAntimicrobial PeptidesSkinSkin NeoplasmsAnimalsbeta-DefensinsCathelicidinsHumansImmunity, InnatePeptidesRibonucleasesS100 Calcium Binding Protein A7S100 ProteinsSkin MicrobiomeAntimicrobial Cationic PeptidesAntimicrobial Peptidesbeta-DefensinsCathelicidinsdermcidinPeptidesRibonuclease 7RibonucleasesS100A7 protein, humanS100 Calcium Binding Protein A7S100 Proteinsantimicrobial peptidescathelicidincutaneous microbiomedefensinsdermcidinmelanomapsoriasinskin cancer

Identifiers

PMID42576411
PMCPMC13457997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.