Evidence map›Paper›PMID 42576383›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

Integrin α7 defines a profibrotic adipose stromal population targeted for nanoparticle PAI-1 gene silencing in obesity.

Linda Mota, David Zhang, Yulieth Soto Ortiz, Federico Zertuche Gonzalez, Eunhee Chung, Caleb Dang, Achraf Noureddine, Eric M Brey, Maria A Gonzalez Porras

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linda MotaDepartment of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.
David ZhangDepartment of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.
Yulieth Soto OrtizDepartment of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.
Federico Zertuche GonzalezDepartment of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.
Eunhee ChungDepartment of Kinesiology, University of Texas at San Antonio, San Antonio, TX, USA.
Caleb DangDepartment of Chemical and Biological Engineering, University of New Mexico, Albuquerque, NM, USA.
Achraf NoureddineDepartment of Chemical and Biological Engineering, University of New Mexico, Albuquerque, NM, USA.
Eric M BreyDepartment of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.
Maria A Gonzalez PorrasDepartment of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA. Electronic address: maria.gonzalezporras@utsa.edu.

Funding

Development of drug delivery system that modulates adipose tissue function.R56DK144158 · NIDDK · UNIVERSITY OF TEXAS SAN ANTONIO · PI GONZALEZ PORRAS, MARIA ALEJANDRA · 2025 to 2025
$221k
NIDDK NIH HHS R56 DK144158
6 · The paper itself

Abstract

Obesity-associated metabolic dysfunction is driven not only by adipocyte expansion but also by pathological remodeling of adipose tissue mediated by distinct stromal cell subpopulations. However, the lack of strategies to selectively interrogate and therapeutically modulate these pathogenic cells has limited clinical progress. Here, we identify integrin α7 (ITGA7)-expressing adipose stromal cells (ASCs) as a proinflammatory and profibrotic population that contributes to adipose tissue dysfunction in obesity and introduce a targeted nanotherapy to selectively reprogram their inflammatory signaling. ITGA7

Indexed as

adipose stromal cellsASCsfibrosisintegrin alpha 7ITGA7LCMSNslipid-coated mesoporous silica nanoparticlesobesityPAI-1SERPINE1siRNA deliverytargeted nanotherapy

Identifiers

PMID42576383
PMCPMC13613333

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.