Evidence map›Paper›PMID 42575976›Full record

ArticleNature nanotechnology2026

Oral nano-delivery of a gut microbial metabolite enhances T cell stemness for cancer immunotherapy.

Kai Han, Young Seok Cho, Mariko Takahashi, Xingwu Zhou, Hannah E Dobson, Kim Hutchings, Yuesong Wu, Youngseo Na, Fang Xie, Julia Crowther and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature nanotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Kai Han *Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA. kaihan@cpu.edu.cn.ORCID http://orcid.org/0000-0001-5370-4296
Young Seok Cho *Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA. youngscho@skku.edu.ORCID http://orcid.org/0000-0003-1338-3170
Mariko TakahashiDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-2465-7907
Xingwu ZhouDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5977-2185
Hannah E DobsonDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1246-880X
Kim HutchingsVahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Yuesong WuDepartment of Statistics and Probability, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0009-0000-5397-1167
Youngseo NaDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5501-3728
Fang XieDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0002-5800-2132
Julia CrowtherDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0009-7357-2046
Jinmei WuState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Jin XuDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8842-9327
Chuan LeeDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
Himani JasewiczGraduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA.
Yujin KimDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-7186-221X
Minal NenwaniBiointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
Olamide AnimasahunBiointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4032-3619
Fulei WuchuBiointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
Anthony AndrenDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Harrison WongDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Emma CampDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Ziye WanDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
Qi WuDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2550-3769
Li ZhangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Cheng XuDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
Katherine DongDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
Yao XuDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
Anna SchwendemanDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
Grace Y ChenDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Yuying XieDepartment of Statistics and Probability, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0002-1049-2219
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9309-6141
Martin ClasbyVahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Deepak NagrathBiointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8999-2282
Yu Leo LeiDepartment of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-9868-9824
James J MoonDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA. moonjj@umich.edu.ORCID http://orcid.org/0000-0003-2238-2372

Funding

New Engineering Strategy for Harnessing Immune System against Head and Neck CancerR01DE030691 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEI, YU LEO, MOON, JAMES J. · 2021 to 2025
$2.9M
Biomaterials for modulating the gut microbiome for immune activationR01CA271799 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI James J. Moon, Deepak Nagrath · 2022 to 2026
$2.7M
NCI NIH HHS R01 CA271799NIAID NIH HHS HHSN272201300006CNIDCR NIH HHS R01 DE030691U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA271799U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE030691
6 · The paper itself

Abstract

Gut microbial metabolites play crucial roles in regulating systemic immunity, but their mechanisms and limited drug-like properties remain unresolved. Here we report an oral nano-formulation that leverages gut microbial metabolites to modulate T cell metabolism and amplify antitumour immunity. Through an in vitro screening of gut microbial metabolites, we identified 3,4-dihydroxybenzoic acid that improved adoptive T cell therapy and enhanced CD8

Indexed as

CD8-Positive T-LymphocytesGastrointestinal MicrobiomeImmunotherapyNeoplasmsAdministration, OralAnimalsCell Line, TumorFemaleHumansMiceMice, Inbred C57BLT-Lymphocytes

Identifiers

PMID42575976
PMCPMC13569413

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.