Evidence map›Paper›PMID 42575621›Full record

ReviewThe journal of allergy and clinical immunology. In practice2026

The Food Allergy-Eosinophilic Esophagitis Continuum: Implications for Food Allergy Immunotherapy.

Deepti Vellaichamy Manian, Sayantani B Sindher, Nasim Khavari, Alfred D Doyle, R Sharon Chinthrajah, Benjamin L Wright

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of allergy and clinical immunology. In practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Deepti Vellaichamy ManianDivision of Allergy and Immunology, Kaiser Permanente, San Jose, Calif. Electronic address: allergydocdee@gmail.com.
Sayantani B SindherSean N Parker Center for Allergy and Asthma Research at Stanford University, Stanford, Calif.
Nasim KhavariDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, Calif.
Alfred D DoyleDivision of Allergy, Asthma, and Clinical Immunology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, Ariz.
R Sharon ChinthrajahSean N Parker Center for Allergy and Asthma Research at Stanford University, Stanford, Calif.
Benjamin L WrightDivision of Allergy, Asthma, and Clinical Immunology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, Ariz; Division of Allergy and Immunology, Phoenix Children's, Phoenix, Ariz.

Funding

Mechanisms of adverse gastrointestinal events during oral immunotherapyK23AI158813 · NIAID · MAYO CLINIC ARIZONA · PI Benjamin L. Wright · 2022 to 2026
$949k
NIAID NIH HHS K23 AI158813
6 · The paper itself

Abstract

IgE-mediated food allergy and eosinophilic esophagitis (EoE) represent distinct yet interconnected manifestations of food-induced immune dysregulation. Rather than separate entities, emerging evidence supports a model that is on a continuum, in which clinical phenotypes are determined by antigen exposure patterns, dose, chronicity, and individual immune responses. This relationship has critical implications for food allergy immunotherapy, particularly oral immunotherapy. Among children with IgE-mediated food allergy, EoE prevalence is nearly 100-fold higher than the general population at 4.7%. During oral immunotherapy, gastrointestinal symptoms are common, with confirmed EoE developing in 1% to 10% of participants. Mechanistically, antigen avoidance favors IgE-mediated responses through T follicular helper cells, whereas sustained exposure promotes T

Indexed as

Desensitization, ImmunologicEosinophilic EsophagitisFood HypersensitivityAllergensAnimalsHumansImmunoglobulin ETh2 CellsAllergensImmunoglobulin EEosinophilEosinophilic esophagitisFood allergyOral immunotherapy

Identifiers

PMID42575621
PMCPMC13686699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.