Evidence map›Paper›PMID 42575445›Full record

ArticleThe Journal of biological chemistry2026

A ternary association of KRas, EphA2, and integrins controls PDAC cell behavior.

Mahak Fatima, Nasir Haider, Stuart A Cain, Bipul R Acharya, Megan R Chastney, Junzhe Zha, Matthew C Jones, Stacey Warwood, David Knight, Derek A O'Reilly and 4 more

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mahak FatimaManchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Nasir HaiderCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Stuart A CainManchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Bipul R AcharyaManchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Megan R ChastneyManchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Junzhe ZhaManchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Matthew C JonesManchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Stacey WarwoodBiological Mass Spectrometry Core Facility, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
David KnightBiological Mass Spectrometry Core Facility, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Derek A O'ReillyDepartment of Hepatobiliary and Pancreatic Surgery, Manchester Royal Infirmary, Manchester, UK.
Jonathan D HumphriesManchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Benjamin T GoultBiochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Claus JørgensenCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Martin J HumphriesManchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. Electronic address: martin.humphries@manchester.ac.uk.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, primarily because late detection, a lack of effective therapies and an abundant desmoplastic reaction result in elevated proliferation, invasion, and immune evasion. KRas is the most frequently mutated driver gene in PDAC and, while drugs are now available that target this GTPase, there remains a need for further pharmacological options to treat the disease. As a first step to identify potential targets, this study aimed to define the molecular environment of KRas using proximity proteomics. A KRas

Indexed as

BioIDcancerdesmoplasiaEphA2integrinsKRaspancreaticstroma

Identifiers

PMID42575445
PMCPMC13563243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.