Evidence map›Paper›PMID 42575251›Full record

ArticleVirologica Sinica2026

Pre-existing hemagglutinin-specific antibody levels are associated with B-cell repertoire maturation and antibody breadth after influenza vaccination.

Wei Wang, Yan Sun, Qing Liu, Yidan Xia, Jing Wang, Minhao Hu, Mengyao Kong, Jun He, Rongbao Gao, Yong Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wei WangThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Yan SunThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Qing LiuThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Yidan XiaDepartment of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, 230032, China.
Jing WangThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Minhao HuDepartment of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, 230032, China.
Mengyao KongMicrobiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, 230601, China.
Jun HeMicrobiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, 230601, China; Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, 230032, China. Electronic address: heliosking@sina.com.
Rongbao GaoNHC Key Laboratory of Biosafety, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: rongbaogao@163.com.
Yong GaoThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China; Hefei Infectious Disease Hospital, Hefei, 230000, China. Electronic address: ygao387@ustc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repeated influenza exposures generate complex antibody landscapes, yet how pre-existing antibodies are associated with subsequent vaccine responses remains unclear. We longitudinally tracked 21 adults stratified by pre-vaccination neutralizing titers to examine B-cell dynamics using flow cytometry, B cell receptor (BCR) sequencing, and monoclonal antibody characterization. After vaccination, participants with high baseline titers showed a longitudinal increase in the frequency of HA

Indexed as

Antibodies, ViralB-LymphocytesHemagglutinin Glycoproteins, Influenza VirusInfluenza, HumanInfluenza VaccinesAdultAntibodies, MonoclonalAntibodies, NeutralizingFemaleFlow CytometryHumansLongitudinal StudiesMaleMiddle AgedReceptors, Antigen, B-CellSomatic Hypermutation, ImmunoglobulinAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesReceptors, Antigen, B-CellAntibody breadthB-cell receptor repertoireHemagglutinin (HA)Influenza vaccinationPre-existing antibodies

Identifiers

PMID42575251
PMCPMC13556341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.