Evidence map›Paper›PMID 42573964›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2026

E-cigarette use and Barrett's esophagus: evaluating a new risk in the era of vaping.

Boniface Mensah, Albert E Orhin, Natalie A Y Akoto, Aida Metri, Rachel A Boateng, Seunghee Han, Kevin Eid, Simardeep Singh, Haider A Naqvi, Cadman L Leggett

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Article in Esophagus : official journal of the Japan Esophageal Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Boniface MensahDepartment of Internal Medicine, MedStar Union Memorial Hospital, Baltimore, MD, 21218, USA. bfacemensah@gmail.com.ORCID http://orcid.org/0009-0006-1314-8022
Albert E OrhinDepartment of Internal Medicine, Saint Agnes Hospital, MD, Baltimore, USA.
Natalie A Y AkotoDepartment of Internal Medicine, MedStar Union Memorial Hospital, Baltimore, MD, 21218, USA.
Aida MetriDepartment of Internal Medicine, MedStar Union Memorial Hospital, Baltimore, MD, 21218, USA.
Rachel A BoatengBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Seunghee HanDepartment of Internal Medicine, MedStar Union Memorial Hospital, Baltimore, MD, 21218, USA.
Kevin EidDepartment of Internal Medicine, MedStar Union Memorial Hospital, Baltimore, MD, 21218, USA.
Simardeep SinghDepartment of Internal Medicine, MedStar Union Memorial Hospital, Baltimore, MD, 21218, USA.
Haider A NaqviDepartment of Internal Medicine, MedStar Franklin Square Hospital, Baltimore, MD, USA.
Cadman L LeggettDepartment of Gastroenterology and Hepatology, Mayo Clinic, Rochester,, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe association between electronic cigarette (e-cigarette) use and Barrett's esophagus (BE) is still unclear. While traditional, combustible cigarette smoking is a known risk factor for BE, growing evidence on e-cigarette exposure has raised concerns about potential esophageal injury. Our aim is to evaluate the relationship between e-cigarette use and BE in a large and diverse population.

methodsWe conducted a cross-sectional analysis using the All of Us Research Program to examine the association between e-cigarette use and BE. Adults aged 18 years or older with an ICD-10 diagnosis of BE (K22.7) were included. E-cigarette exposure was categorized as (1) ever vs. never use, (2) former vs. current vs. never use, and (3) dual use (concurrent e-cigarette and traditional cigarette smoking). Covariates including demographics, BMI, smoking status, alcohol use, GERD, hiatal hernia, diabetes, NSAID use, education, income, employment, and insurance status, were obtained. Multivariable logistic regression estimated adjusted odds ratios (AORs) with 95% confidence intervals.

resultsAmong the 328,022 individuals studied, 29,343 (9%) reported e-cigarette use. E-cigarette users were younger and had lower rates of diabetes and GERD. After adjusting for relevant factors, we found that ever e-cigarette use was associated with higher odds of BE (OR 1.21, 95% CI 1.06-1.39). When we stratified by patterns of use, current e-cigarette use was significantly associated with BE (OR 1.46, 95% CI 1.15-1.83), whereas former use was not (OR 1.12, 95% CI 0.96-1.31). Individuals who were dual users also had increased odds of BE (OR 1.22, 95% CI 1.05-1.41). As expected, smoking, older age, hiatal hernia, and GERD remained strong predictors across all models, with GERD showing the strongest relationship. DISCUSSION: In this large national cohort, current and dual e-cigarette use were associated with increased odds of BE after adjustment for established risk factors, including GERD and combustible cigarette smoking. These findings suggest that e-cigarette use may represent a modifiable and underrecognized contributor to esophageal mucosal injury. Prospective longitudinal studies are needed to establish causality and clarify the mechanisms underlying this association.

Indexed as

Barrett’s esophagusE-cigarette smokingEsophageal adenocarcinomaTobacco smoking

Identifiers

PMID42573964

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.