Evidence map›Paper›PMID 42573924›Full record

ArticleJournal of neuro-oncology2026

Socioeconomic factors associated with post-operative biochemical remission in acromegaly.

Aymen S Kabir, Zain Peeran, Robert C Osorio, Poojan Shukla, Aarav Badani, Harmon S Khela, Paul McMillan Villalobos, Philip Theodosopoulos, Jose G Gurrola, Ivan H El-Sayed and 3 more

Abstract read
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Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aymen S KabirDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA.
Zain PeeranDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA.
Robert C OsorioDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA.
Poojan ShuklaDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA.
Aarav BadaniDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA.
Harmon S KhelaDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA.
Paul McMillan VillalobosDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA.
Philip TheodosopoulosDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA.
Jose G GurrolaDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, USA.
Ivan H El-SayedDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, USA.
Lewis S BlevinsDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA.
Sandeep KunwarDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA.
Manish K AghiDepartment of Neurological Surgery, University of California, San Francisco 505 Parnassus Ave., M-779, San Francisco, CA, 94143, USA. manish.aghi@ucsf.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGrowth Hormone (GH)-secreting pituitary neuroendocrine tumors (PitNETs) are the leading cause of acromegaly, yet predictors of postoperative biochemical remission remain incompletely defined. This study evaluated the association between socioeconomic status (SES) and the likelihood of biochemical remission after transsphenoidal resection.

methodsThe authors retrospectively reviewed 184 patients who underwent transsphenoidal resection for GH-secreting PitNETs at a single institution. Demographic, socioeconomic, and clinical variables included sex, race, ethnicity, language proficiency, insurance, primary care provider status, zip code-based median household income, and preoperative IGF-1 levels expressed as a multiple of the upper limit of normal (mULN). Biochemical remission was defined as postoperative normalization of age- and sex-adjusted insulin-like growth factor 1 together with a postoperative random GH level < 1.0 ng/mL or a GH level ≤ 0.4 ng/mL following oral glucose tolerance testing within 6 months after surgery, without postoperative medical therapy, radiotherapy, or repeat surgery. Associations were evaluated using univariable comparisons and multivariable logistic regression.

resultsOf 184 patients, 111 met the combined IGF-1 and GH criteria for postoperative biochemical remission. Patients who achieved remission lived in zip codes with higher median household income than non-remitters ($107,000 vs. $93,000; p = 0.015). In multivariable logistic regression, the lowest income tertile was associated with lower odds of remission compared with the high-income tertile (OR 0.29, 95% CI 0.10-0.83, p = 0.021).

conclusionZip code-based median household income was associated with a higher likelihood of biochemical remission after surgery for acromegaly, suggesting that SES may represent an important determinant of postoperative endocrine outcomes.

Indexed as

AcromegalyGrowth Hormone-Secreting Pituitary AdenomaPituitary NeoplasmsSocioeconomic FactorsAdultAgedFemaleFollow-Up StudiesHuman Growth HormoneHumansInsulin-Like Growth Factor IMaleMiddle AgedPostoperative PeriodPrognosisRemission InductionHuman Growth HormoneInsulin-Like Growth Factor IAcromegalyDisparitiesPituitary adenomaRemissionSocioeconomic status

Identifiers

PMID42573924

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.