Evidence map›Paper›PMID 42573864›Full record

ArticleTropical animal health and production2026

Gene expression of adipokines in placentas of cows from Northeastern Brazil with and without hyperketonemia and their interactions with metabolic biomarkers.

Ângela Imperiano da Conceição, João Victor José de Barros Dantas, Carla Lopes de Mendonça, Jobson Filipe de Paula Cajueiro, Rodolfo José Cavalcanti Souto, Licarion Pinto, Daniel Nunes de Araújo Gonçalves, Paulo Roberto Eleutério de Souza, José Augusto Bastos Afonso, Pierre Castro Soares

Abstract read
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In one paragraph

Article in Tropical animal health and production, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ângela Imperiano da ConceiçãoPostgraduate Program in Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil. angelaimperiano@hotmail.com.ORCID http://orcid.org/0000-0002-0422-4912
João Victor José de Barros DantasDepartment of Biology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0009-0008-7624-0998
Carla Lopes de MendonçaFederal Rural University of Pernambuco, Cattle Clinic, Garanhuns, Pernambuco, Brazil.ORCID http://orcid.org/0000-0002-4985-4985
Jobson Filipe de Paula CajueiroFederal Rural University of Pernambuco, Cattle Clinic, Garanhuns, Pernambuco, Brazil.ORCID http://orcid.org/0000-0003-3228-2383
Rodolfo José Cavalcanti SoutoFederal Rural University of Pernambuco, Cattle Clinic, Garanhuns, Pernambuco, Brazil.ORCID http://orcid.org/0000-0003-3380-5596
Licarion PintoDepartment of Analytical Chemistry, Institute of Chemistry, State University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-8682-6174
Daniel Nunes de Araújo GonçalvesDepartment of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0000-0002-0664-1621
Paulo Roberto Eleutério de SouzaDepartment of Biology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0000-0002-9186-9849
José Augusto Bastos AfonsoFederal Rural University of Pernambuco, Cattle Clinic, Garanhuns, Pernambuco, Brazil.ORCID http://orcid.org/0000-0002-6558-644X
Pierre Castro SoaresDepartment of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0000-0002-5680-3940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective was to analyze the mRNA expression of leptin, leptin receptor (ObRb), adiponectin, adiponectin receptor (AdipoR1), and resistin in the placental tissue of cows with and without hyperketonemia, relating it to their metabolic profile. Samples were collected from 135 cows during birth, divided into two groups: G1: without hyperketonemia (n = 120) and G2: with hyperketonemia (n = 15). Biochemical and hormonal indicators and insulin sensitivity were evaluated. Placental fragments were analyzed by qPCR. The variables were tested for normality and Pearson's correlation coefficient was applied. The significance level was 5%. Cows with hyperketonemia showed increased concentrations of NEFA (p = 0.0002), urea (p = 0.0302), higher expressions of leptin (p = 0.0174) and ObRb (p < 0.0001), while healthy cows showed higher expression of AdipoR1 (p < 0.0001) and resistin (p = 0.0435). Glucose concentrations were lower in G2 (p = 0.0132), as were the percentages of RQUICKI

Indexed as

AdipokinesCattle DiseasesKetosisPlacentaAdiponectinAnimalsBiomarkersBrazilCattleFemaleGene ExpressionLeptinPregnancyRNA, MessengerAdipokinesAdiponectinBiomarkersLeptinRNA, MessengerAdiponectinCattleKetosisLeptinMultivariate analysis

Identifiers

PMID42573864
PMCPMC13457270

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.