Evidence map›Paper›PMID 42573857›Full record

ReviewCurrent cardiology reports2026

The Intersection of Androgens and Cardiovascular Disease in Postmenopausal Women.

Michelle L Dew, Olubunkola M Olubi, Caroline Wang-Crocker, Emily L Prince, Annslee Lowe, D Elizabeth Le

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michelle L DewCardiology and Cardiothoracic Department, AdventHealth Shawnee Mission, Shawnee Mission, KS, USA.
Olubunkola M OlubiDivision Cardiology, Piedmont Heart Institute, Fayetteville, GA, USA.
Caroline Wang-CrockerDepartment of Internal Medicine, Oregon Health & Science University, Portland, OR, USA.
Emily L PrinceDepartment of Internal Medicine, Oregon Health & Science University, Portland, OR, USA.
Annslee LoweDepartment of Internal Medicine, Oregon Health & Science University, Portland, OR, USA.
D Elizabeth LeDivision of Cardiology, Portland Veterans Administration Health Care System, 3710 SW US Veterans Hospital Road P3CAR, Portland, OR, 97239, USA. lee@ohsu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewTo summarize the current understanding of the relationships between endogenous and exogenous androgens and cardiovascular disease in postmenopausal women. RECENT

findingsEndogenous testosterone and dehydroepiandrosterone exhibit a J-shaped relationship with cardiovascular mortality. The association of exogenous testosterone with adverse cardiovascular outcomes is highly dependent on dose and route of administration. Non-oral testosterone administration is associated with neutral risks, but close monitoring of total testosterone levels is obligatory. Estrogen, progesterone, and androgens levels shift during menopause transition, and the ratios between levels have a greater impact on cardiometabolic and cardiovascular outcomes than absolute levels. While exogenous testosterone modestly improves hypoactive sexual desire, it is unknown if restoring testosterone levels to premenopausal physiologic conditions can also mitigate other age-related physical changes. Future studies addressing the timing, dose, route of administration, treatment duration, and combination therapy with estrogen in postmenopausal women of all racial and ethnicities are needed.

Indexed as

AndrogensCardiovascular DiseasesPostmenopauseTestosteroneDehydroepiandrosteroneEstrogensFemaleHumansAndrogensDehydroepiandrosteroneEstrogensTestosteroneAndrogensCardiovascular diseaseMenopauseTestosterone

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.