ArticleCell and tissue banking2026
Influence of dextran deswelling on graft preparation and clinical outcomes in DMEK.
Article in Cell and tissue banking, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To evaluate the influence of dextran-containing versus dextran-free organ culture media on graft preparation characteristics and postoperative outcomes following Descemet Membrane Endothelial Keratoplasty (DMEK). In this single-center retrospective comparative study, 31 organ-cultured corneoscleral donor rims obtained from the Eye Bank of the University Hospital of Cologne between 2018 and 2022 were analyzed. Donor age ranged from 52 to 74 years. Donor tissues were allocated to either dextran-containing organ culture medium (group A, n = 16) or dextran-free medium (group B, n = 15) according to logistical and surgical scheduling considerations. Intraoperative graft preparation characteristics were assessed using a standardized scoring system evaluating Descemet membrane splitting and stripping behavior, graft fragility, and central and peripheral attachment tendencies. Postoperative outcome parameters included Best Spectacle-Corrected Visual Acuity (BSCVA), central and peripheral corneal thickness (CCT and PCT), endothelial cell count (ECC), and re-bubbling rate over a follow-up period of 12 months after DMEK. All 31 DM-endothelium grafts were successfully prepared and transplanted for DMEK. No significant differences were observed between swollen and dextran-deswollen grafts regarding intraoperative preparation characteristics, including stripping behavior (p = 0.722), graft fragility (p = 0.433), peripheral attachment tendency (p = 1.000), and central tearing tendency (p = 0.484). Descemet membrane splitting behavior was also comparable between groups. At 12 months postoperatively, no significant differences were detected between groups regarding CCT (group A: 517.67 ± 15.10 µm vs. group B: 530.10 ± 24.92 µm; p = 0.189) or re-bubbling rate (p = 0.704). A trend toward lower PCT was observed in group B (group A: 604.00 ± 21.67 µm vs. group B: 579.50 ± 36.12 µm; p = 0.063), accompanied by a trend toward higher ECC in group B (group A: 1387 ± 131 cells/mm
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