ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Sex differences in chemotherapy-induced alopecia distress using the Japanese version of the Chemotherapy-Induced Alopecia Distress Scale.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeWhile chemotherapy-induced alopecia (CIA) is a concern for patients with cancer, investigations involving men with CIA are limited. We aimed to examine sex differences in chemotherapy-related distress using the Japanese version of the Chemotherapy-Induced Alopecia Distress Scale (CADS-J).
methodsThe study, conducted at Toranomon and Yokohama Minami Kyosai Hospitals between March and December 2023, employed a one-time 17-item questionnaire survey (CADS-J) for patients with cancer who had not previously experienced CIA-related hair loss. Each item was scored from 0 (none) to 3 (severe), with total scores ranging from 0 to 51.
resultsOf 104 patients who received the questionnaire, 97 were included in the analysis (men, 55 [56.7%]; mean age, 62.6 ± 12.7 years). Metastatic disease was present in 92.7% and 50% of the men and women, respectively. Pancreatic (35%) and gastric (16%) cancers were most common in the men; while pancreatic (26%) and breast (24%) cancers were most common in the women. Common terminology criteria for adverse events (CTCAE) grade 2 CIA was observed in 70.9% and 95.2% of the men and women, respectively. Mean CADS-J total scores were: men, 5.7; women, 13.2 (p < 0.001); women scored significantly higher in every domain. In a multivariable analysis, female sex, wig or hat use, and depressive symptoms (Center for Epidemiologic Studies Depression Scale ≥ 16) were independently associated with higher CADS-J total scores. Among the men, 5/55 (9.1%) had CADS-J total scores ≥ 13 (the female mean); of whom four (80%) had CTCAE grade 2 CIA and wore a wig or hat.
conclusionTo our knowledge, this is the first study to report sex differences in distress associated with CIA using CADS-J. Distress was stronger in women, but some men also experienced marked distress. Further research and clinical evaluations are needed to individualize targeted care.
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