Evidence map›Paper›PMID 42573811›Full record

ArticlePediatric surgery international2026

Renal outcomes and compensatory hypertrophy in survivors of unilateral non-syndromic Wilms tumour: a single-centre cross-sectional study from a tertiary-care institution in India.

Monikha Potturu, Mehak Sehgal, Aditi Sinha, Manisha Jana, Krithika Rangarajan, Sudip Kumar Datta, Rakesh Kumar, Nilima Nilima, Devendra Kumar Yadav, Prabudh Goel and 5 more

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Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Monikha PotturuDepartment of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), 7th Floor, Paediatric Surgery Office, Mother and Child Block, New Delhi, 110029, India.
Mehak SehgalDepartment of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), 7th Floor, Paediatric Surgery Office, Mother and Child Block, New Delhi, 110029, India.
Aditi SinhaDivision of Nephrology, Department of Paediatrics, All India Institute of Medical Sciences (AIIMS), 8th Floor, Mother and Child Block, New Delhi, 110029, India.
Manisha JanaDepartment of Radiodiagnosis, All India Institute of Medical Sciences (AIIMS), Old RAK Block, New Delhi, 110029, India.
Krithika RangarajanDepartment of Radiodiagnosis (IRCH), B.R.A.IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.
Sudip Kumar DattaDepartment of Laboratory Medicine, All India Institute of Medical Sciences (AIIMS), New RAK Block, New Delhi, 110029, India.
Rakesh KumarDepartment of Nuclear Medicine, All India Institute of Medical Sciences (AIIMS), Old RAK Block, New Delhi, 110029, India.
Nilima NilimaDepartment of Biostatistics, All India Institute of Medical Sciences (AIIMS), Biotechnology Block, New Delhi, 110029, India.
Devendra Kumar YadavDepartment of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), 7th Floor, Paediatric Surgery Office, Mother and Child Block, New Delhi, 110029, India.
Prabudh GoelDepartment of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), 7th Floor, Paediatric Surgery Office, Mother and Child Block, New Delhi, 110029, India.
Sandeep AgarwalaDepartment of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), 7th Floor, Paediatric Surgery Office, Mother and Child Block, New Delhi, 110029, India.
Anjan Kumar DhuaDepartment of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), 7th Floor, Paediatric Surgery Office, Mother and Child Block, New Delhi, 110029, India.
M SrinivasDepartment of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), 7th Floor, Paediatric Surgery Office, Mother and Child Block, New Delhi, 110029, India.
Divya GaliDepartment of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), 7th Floor, Paediatric Surgery Office, Mother and Child Block, New Delhi, 110029, India.
Vishesh JainDepartment of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), 7th Floor, Paediatric Surgery Office, Mother and Child Block, New Delhi, 110029, India. dr.vishesh79@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study evaluated renal outcomes and contralateral compensatory hypertrophy in Unilateral Wilms tumour survivors because of a solitary functioning kidney which is vulnerable to hyperfiltration injury.

methodsThis cross-sectional study (January 2005-May 2023) included children with non-syndromic unilateral Wilms tumour. Renal function was assessed using the modified Schwartz formula (eGFR), 99mTc-DTPA plasma clearance and urinary albumin/creatinine ratio(ACR). Blood pressure was evaluated by office measurement and 24-hour ambulatory blood pressure monitoring (ABPM). Compensatory hypertrophy was assessed by CT volumetric segmentation.

resultsA total of 117 children were included (median age 84 months, IQR 60-120; median follow-up 40.7 months, IQR 16.6-74.3). Reduced eGFR (< 90 ml/min/1.73 m²) was identified in 14 of 116 (12.1%), and reduced 99mTc-DTPA plasma clearance in 38 of 55 (69.1%). Microalbuminuria was identified in 7 of 56 (12.5%), ABPM-detected hypertension in 4 of 48 (8.3%), and compensatory hypertrophy in 36 of 48 (75.0%). Applying the composite definition (any of: low eGFR, low DTPA GFR, microalbuminuria or ABPM-detected hypertension), renal dysfunction was present in 53 of 117 patients (45.3%). In a analysis restricted to the 31 patients who completed all four investigations, renal dysfunction was present in 25 of 31 (80.6%).

conclusionIsotopic GFR revealed silent nephron injury despite compensatory hypertrophy, with nearly half showing renal dysfunction undetected by creatinine-based eGFR. Creatinine-based eGFR alone risks under-detecting renal dysfunction.

Indexed as

KidneyKidney NeoplasmsSolitary KidneyWilms TumorChildChild, PreschoolCross-Sectional StudiesFemaleGlomerular Filtration RateHumansHypertrophyIndiaMaleTertiary Care CentersAmbulatory blood pressure monitoringCompensatory renal hypertrophyFollow-upWilms tumourWilms tumour survivors

Identifiers

PMID42573811

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.