Evidence map›Paper›PMID 42573744›Full record

ArticleJournal of anesthesia2026

Association between lactate-to-albumin ratio and postoperative delirium in elderly patients undergoing cardiac surgery.

Wenjie Zhu, Yuyan Wang, Rongrong Zhang, Xiaohu Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Wenjie Zhu *Department of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Yuyan Wang *Department of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Rongrong ZhangDepartment of Ultrasound, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Xiaohu YangDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. shuaitiger@163.com.

Funding

Shanghai East Hospital 2024-DFZD- 005 (MDX)Shanghai Municipal Health Commission 2024ZDXK0001(MDX)the Medical Discipline Construction Project of Pudong Health Committee of Shanghai 2024-PWXZ-07 (MDX)the Medical Discipline Construction Project of Pudong Health Committee of Shanghai 2025PDWSYCBJ-01 (TC)the Medical Discipline Construction Project of Pudong Health Committee of Shanghai PWZxq2022-6 (MDX)
6 · The paper itself

Abstract

purposePostoperative delirium (POD) is highly prevalent among patients undergoing cardiac surgery, particularly in older adults. The lactate-to-albumin ratio (LAR), a composite biomarker reflecting both hypoxia and inflammatory pathways, could help elucidate the pathophysiological mechanisms underlying POD. This study aimed to determine the relationship between preoperative LAR and POD and to evaluate the potential predictive value of LAR.

methodsThis retrospective cohort analysis utilized data extracted from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Patients eligible for inclusion were those ≥65 years of age and having received cardiac surgery. Hierarchical multivariable logistic regression assessed associations, controlling for multicollinearity (VIF) and modeling non-linearity (RCS). Predictive performance was evaluated using Youden index, AUC (DeLong), NRI, IDI, likelihood ratio tests and trend analysis.

resultsThis retrospective study analyzed data from 1770 elderly patients undergoing cardiac surgery. Of the 1770 patients, 412 (23.28%) developed postoperative delirium, and 131 (7.40%) died during hospitalization. Patients in the high LAR group had a 1.51-fold increased risk of POD compared to the low LAR group (adjusted OR=1.51, 95% CI 1.18-1.95, p < 0.005), and LAR as a continuous variable was independently associated with POD (adjusted OR=1.71 per unit increase, 95% CI 1.20-2.44, p = 0.003). After adjusting for confounding factors, this relationship was attenuated. Nevertheless, higher LAR remained independently associated with a higher risk of POD (all p< 0.05).

conclusionThe results showed that a higher preoperative lactate/albumin ratio (LAR) was independently associated with an increased risk of postoperative delirium (POD) in elderly patients undergoing cardiac surgery, and that there was a non-linear relationship between LAR and the incidence of POD.

Indexed as

Cardiac surgeryElderly patientsLactate-to-albumin ratioPostoperative deliriumRisk factor

Identifiers

PMID42573744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.