Evidence map›Paper›PMID 42573736›Full record

ArticleJMIR formative research2026

An Interactive Narrative Intervention to Increase Adolescents' Knowledge and Self-Efficacy to Reduce Alcohol Use: Pre-Post Study.

Carlos Penilla, Mark S Berna, Marianne Pugatch, Vikram Kumaran, Sean Hennigan, Kathleen P Tebb, Sara Buckelew, Anoushka Sinha, Jonathan P Rowe, Alison Giovanelli and 4 more

Abstract read
In one paragraph

Article in JMIR formative research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Carlos Penilla *Department of Pediatrics, University of California San Francisco, 550 16th Street, #4241, San Francisco, CA, 94158, United States, 1 415-502-2606.ORCID 0000-0002-2212-5432
Mark S Berna *Department of Pediatrics, University of California San Francisco, 550 16th Street, #4241, San Francisco, CA, 94158, United States, 1 415-502-2606.ORCID 0009-0007-6703-3527
Marianne Pugatch *Department of Psychiatry and Behavioral Medicine, Northwestern University Feinburg School of Medicine, Chicago, IL, United States.ORCID 0000-0003-0315-1501
Vikram Kumaran *Department of Computer Science, North Carolina State University, Raleigh, NC, United States.ORCID 0009-0009-6257-4732
Sean Hennigan *Department of Pediatrics, University of California San Francisco, 550 16th Street, #4241, San Francisco, CA, 94158, United States, 1 415-502-2606.ORCID 0009-0001-1983-1600
Kathleen P Tebb *Department of Pediatrics, University of California San Francisco, 550 16th Street, #4241, San Francisco, CA, 94158, United States, 1 415-502-2606.ORCID 0000-0002-6401-7923
Sara Buckelew *Department of Pediatrics, University of California San Francisco, 550 16th Street, #4241, San Francisco, CA, 94158, United States, 1 415-502-2606.ORCID 0000-0001-8252-0293
Anoushka Sinha *Department of Pediatrics, University of California San Francisco, 550 16th Street, #4241, San Francisco, CA, 94158, United States, 1 415-502-2606.ORCID 0000-0002-0967-6870
Jonathan P Rowe *Applied Research Associates, Raleigh, NC, United States.ORCID 0000-0003-2038-9239
Alison Giovanelli *Department of Pediatrics, University of California San Francisco, 550 16th Street, #4241, San Francisco, CA, 94158, United States, 1 415-502-2606.ORCID 0000-0002-5336-5674
James C Lester *Department of Computer Science, North Carolina State University, Raleigh, NC, United States.ORCID 0000-0003-1481-6601
Courtney Barron *Department of Computer Science, North Carolina State University, Raleigh, NC, United States.ORCID 0009-0004-0664-0073
Leslie Einhorn *Children's After School Arts, San Francisco, CA, United States.ORCID 0009-0002-5290-2148
Elizabeth M Ozer *Department of Pediatrics, University of California San Francisco, 550 16th Street, #4241, San Francisco, CA, 94158, United States, 1 415-502-2606.ORCID 0000-0001-8680-4453

Funding

SCH: ChangeGradients: Promoting Health Behavior Change with Clinically Integrated Sample-Efficient Policy Gradient MethodsR01CA247705 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OZER, ELIZABETH M · 2020 to 2023
$1.4M
Department of Health and Human Services (HHS) UA6MC27378National Science Foundation IIS-1344670National Science Foundation IIS-1344803NCI NIH HHS R01 CA247705the UniHealth Foundation T71MC00003
6 · The paper itself

Abstract

Background: Accidents and injuries are the leading causes of preventable death among adolescents and are often related to substance use. About 60% of US high school students have tried alcohol and 22% report current alcohol use. Preventing and reducing adolescent alcohol use would contribute to substantial health benefits and prevent major health morbidity and mortality. Advances in interactive narrative learning technologies hold promise for designing games for health that effectively deliver age-appropriate and personalized behavior change interventions. The Interactive Narrative System for Patient-Individualized Reflective Exploration (INSPIRE) is designed to serve as an extension to clinical preventive care, engaging adolescents in a theoretically grounded alcohol prevention intervention by leveraging the dual mechanisms of interactive narrative and 3D game technologies. Objective: This pre-post study aims to examine the impact of INSPIRE on adolescents' self-efficacy to avoid risky alcohol-related behavior and knowledge about alcohol risk. Methods: A total of 44 adolescents in high school (aged 14-16 years; mean 15.16, SD 0.95; n=22, 50% female) were recruited using convenience sampling from an after-school program in the San Francisco Bay Area. The largest proportion of participants identified as Hispanic or Latine (n=15, 34%), followed by White, Asian, and multiple racial or ethnic backgrounds. Participants completed two 20-minute web-based interactive narrative episodes. We compared pretest and posttest data to examine changes in adolescents' self-efficacy and knowledge using a combination of questionnaire and computer interaction trace log data. Self-efficacy was measured using a 24-item scale (α=.95; 0-10 rating). Knowledge was assessed using 10 multiple-choice items derived from in-game content. Pre-post changes were analyzed using Wilcoxon signed-rank tests (α=.05), with rank-biserial correlation effect sizes and 95% CIs. Results: Approximately 25% (n=11, 95% CI 14.6%-39.4%) of study participants reported having consumed alcohol at least once, and 23% (n=10, 95% CI 12.8%-37.0%) reported alcohol use within the past year. Self-efficacy scores significantly increased from 7.97 (SD 2.24) at pretest to 8.72 (SD 1.58) at posttest, with a mean difference of 0.75 (95% CI 0.59-0.91; P<.001; r=0.89). Knowledge scores also significantly increased from 5.09 correct (median 5.0, IQR 4.0-6.0) at pre-test to 6.11 correct (median 7.0, IQR 5.0-8.0) at posttest, with a mean increase of 1.02 (95% CI 0.31-1.74; Wilcoxon signed-rank test, P<.001; r=0.57). Reflection tool clustering revealed 4 behavioral strategy endorsement profiles. Conclusions: As a first of its kind interactive narrative intervention, INSPIRE offers an innovative theoretically grounded model for supporting adolescent health behavior change. This study enhances our understanding of how to use innovative learning technologies to reduce risky alcohol use. Extending prior research in the field through using personalized narrative adaptations, this study indicates that through reinforcing goals and decisions to avoid risky behavior, adolescents can enhance their self-efficacy beliefs to avoid risky alcohol use and increase their knowledge about alcohol risk. Implications of these outcomes include the potential to facilitate the generalization of preventive behaviors to real-life situations.

Indexed as

Adolescent BehaviorHealth Knowledge, Attitudes, PracticeNarrationSelf EfficacyUnderage DrinkingAdolescentFemaleHumansMaleSan FranciscoSurveys and Questionnairesadolescentsalcohol useclinic-based interventiongame technologyinteractive narrative

Identifiers

PMID42573736
PMCPMC13455581

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.