ArticleMethods in molecular biology (Clifton, N.J.)2026
Reporter Gene Assay for Monitoring BCL6 Reactivation.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Transcription factors are an exciting class of drug targets. Recent developments in small molecule-induced proximity allow for small molecule control of their activity by recruitment of epigenetic proteins. In this chapter, we describe the development of a transcriptional activity assay for the transcription factor BCL6 with a small molecule activator, TCIP1, in HEK293T cells [1]. The assay is based on the Bio-Glo Luciferase assay system and uses transient transfection of a BCL6-expressing plasmid, as well as a reporter plasmid where a BCL6 DNA-binding sequence controls expression of a luciferase protein. The method described here is specific to BCL6 but can easily be optimized to monitor the activity of other transcription factors by altering the DNA-binding sequence of the reporter.
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