ArticleClinical oral investigations2026
Impact of biopsy-related variables on MRI assessment of tumor invasion in early oral squamous cell carcinoma.
Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the impact of incisional biopsy technique and biopsy-to-MRI interval on the concordance between radiological and pathological depth of invasion (DOI) in early-stage oral squamous cell carcinoma (OSCC).
methodsA retrospective cohort study included 47 patients with early-stage OSCC who underwent incisional biopsy, MRI, and surgical resection. After excluding non-invasive tumors and cases with unreliable radiological DOI (r-DOI) assessment, 22 patients were analyzed. r-DOI was independently measured by two radiologists and compared with pathological DOI (p-DOI) from surgical specimens. The effects of biopsy technique ("cold blade" vs. "forceps") and biopsy-to-MRI interval on DOI concordance were evaluated using Lin's concordance correlation coefficient, Bland-Altman analysis, and the Mann-Whitney test.
resultsMRI overestimated DOI by a mean of 2.95 ± 2.71 mm compared with pathology (limits of agreement: -2.37 to 8.26 mm), showing weak-to-moderate concordance (Lin's CCC = 0.494, 95% CI: 0.23-0.69; Spearman's ρ = 0.563, 95% CI: 0.18-0.80). DOI discrepancy was not significantly associated with biopsy technique (p = 0.61) or biopsy-to-MRI interval (p = 0.79).
conclusionsMRI tends to overestimate DOI in early-stage OSCC irrespective of biopsy technique or imaging timing. Given the prognostic importance of prompt treatment, delaying MRI to reduce presumed biopsy-related overestimation appears unjustified. CLINICAL RELEVANCE: MRI systematically overestimates DOI compared with final histopathology, but this discrepancy does not appear to be influenced by biopsy technique or biopsy-to-MRI interval. Although larger, adequately powered studies are needed, these findings do not support delaying MRI solely to minimize presumed biopsy-related effects on DOI assessment.
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