Evidence map›Paper›PMID 42573532›Full record

ArticleActa orthopaedica2026

Tibial implant migration of cemented and cementless total and unicompartmental knee arthroplasties in patients with low and normal bone mineral density: a 5-year RSA cohort study of 397 cases.

Karina N Linde, Bente L Langdahl, Søren Rytter, Rob G H H Nelissen, Maiken Stilling

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Article in Acta orthopaedica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Karina N LindeDepartment of Orthopaedics, Aarhus University Hospital, Aarhus, Denmark; AutoRSA research group, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. karina.linde@clin.au.dk.
Bente L LangdahlDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Søren RytterDepartment of Orthopaedics, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Rob G H H NelissenDepartment of Orthopedics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-1228-4162
Maiken StillingDepartment of Orthopaedics, Aarhus University Hospital, Aarhus, Denmark; AutoRSA research group, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-4530-2075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposePeriprosthetic bone may influence the longevity of joint implants. We aimed to investigate the association between bone mineral density (BMD) and tibial implant migration of cemented and cementless knee arthroplasty as a surrogate marker of aseptic loosening.

methodsIn a prospective cohort study, patients were operated on between 2014 and 2018 with a unicompartmental knee arthroplasty (UKA) or a total knee arthroplasty (TKA). Preoperative BMD was measured using dual-energy X-ray absorptiometry of the lumbar spine and hips. Patients were categorized into low or normal T-score groups (threshold: T-score ≤ -1.0). Postoperative tibial implant migration was assessed using radiostereometry at baseline and 1-, 2-, and 5-year follow-ups. The primary outcome was 1-year maximum total point motion (MTPM) differences between T-score groups. Secondary outcomes evaluated the association between continuous migration (MTPM > 0.2 mm between 1 and 2 years) and T-score.

results397 patients were included, where 210 patients received a cementless implant (TKA = 78, UKA = 132) and 187 received a cemented implant (TKA = 83, UKA =104). Estimated 1-year mean MTPM differences between the low and normal T-score groups were 0.15 mm (CI -0.25 to 0.55) for cementless TKA, 0.12 mm (CI -0.25 to 0.49) for cemented TKA, -0.21 mm (CI -0.51 to 0.10) for cementless UKA, and -0.15 mm (CI -0.34 to 0.04) for cemented UKA. A 1-unit increase in T-score showed comparable odds of continuous migration within both cemented (OR 0.94, CI 0.68-1.30) and cementless (OR 0.79, CI 0.56-1.12) tibial implants.

conclusionTibial implant migration was not significantly different between patients with low and normal BMD as defined by T-score groups. These findings should be interpreted cautiously due to small group sizes and wide confidence intervals, highlighting the need for further studies to clarify the role of BMD in implant migration.

Indexed as

Arthroplasty, Replacement, KneeBone DensityForeign-Body MigrationKnee ProsthesisProsthesis FailureAbsorptiometry, PhotonAgedBone CementsFemaleHumansMaleMiddle AgedProspective StudiesRadiostereometric AnalysisTibiaBone Cements

Identifiers

PMID42573532
PMCPMC13455171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.