ArticleCNS neuroscience & therapeutics2026
Bard1-Mediated Regulation of Hnrnpa2b1 Ubiquitination and Protein Stability Contributes to Neuronal Ferroptosis and Cognitive Dysfunction Following Ischemic Stroke.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsN6-methyladenosine (m
methodsHT-22 cell damage and ferroptosis were analyzed following OGD exposure. pMCAO surgery was performed to establish an IS mouse model. We assessed neurological deficits and cognitive impairment in mice using the mNSS, adhesive removal test, rotarod test, novel object recognition test, and Y-maze test. Adeno-associated viral vectors with overexpression of Sptbn2 combined with pMCAO surgery were used to analyze cognitive dysfunction and ferroptosis.
resultsSptbn2 was reduced in neurons of PSCI mice. Sptbn2 overexpression alleviated ferroptosis-induced neuronal damage by promoting the membrane translocation of Slc7a11. Hnrnpa2b1 promoted Sptbn2 stability through an m
conclusionIn IS, Bard1-associated regulation of Hnrnpa2b1 ubiquitination is accompanied by reduced Sptbn2 expression and impaired Slc7a11 membrane translocation, and is involved in neuronal ferroptosis-related damage.
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