Evidence map›Paper›PMID 42573264›Full record

ArticleJournal of virology2026

Intragenic transcription from defective HIV proviruses triggers interferon responses in myeloid cells.

Jonathan M Kilroy, Aparna A Deokar, Samantha Patalano, Juan I Fuxman Bass, Manish Sagar, Suryaram Gummuluru, Andrew J Henderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jonathan M Kilroy *Department of Virology, Immunology, and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Aparna A Deokar *Department of Biology, Boston University, Boston, Massachusetts, USA.
Samantha PatalanoDepartment of Biology, Boston University, Boston, Massachusetts, USA.
Juan I Fuxman BassDepartment of Biology, Boston University, Boston, Massachusetts, USA.
Manish SagarDepartment of Virology, Immunology, and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0001-9803-6594
Suryaram GummuluruDepartment of Virology, Immunology, and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-8606-8481
Andrew J HendersonDepartment of Virology, Immunology, and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-9299-5302

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH, DEBBIE M. CHENG · 1998 to 2026
$51.7M
Structure and Function of Immune Gene Regulatory NetworksR35GM128625 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Juan Ignacio Fuxman Bass · 2018 to 2026
$4.0M
Persistent HIV-1 expression and microglia dysfunctionR01DA055488 · NIDA · BOSTON MEDICAL CENTER · PI GUMMULURU, SURYARAM, HENDERSON, ANDREW J · 2021 to 2025
$3.7M
Defective HIV proviruses and Persistent Innate Immune ActivationR01AI187175 · NIAID · BOSTON MEDICAL CENTER · PI SURYARAM GUMMULURU, Andrew J Henderson · 2024 to 2026
$2.4M
BU Undergraduate Research Opportunity ProgramNational Institute of Allergy and Infectious Diseases P30 AI042853National Institute of Allergy and Infectious Diseases R01 AI187175NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI187175NIDA NIH HHS DA055488NIDA NIH HHS R01 DA055488NIGMS NIH HHS R35 GM128625NIGMS NIH HHS R35GM128625
6 · The paper itself

Abstract

The persistent HIV-1 reservoir includes a subset of cells harboring transcriptionally repressed latent HIV-1 that contributes to rebound upon antiretroviral treatment (ART) interruption. However, the majority of the reservoir consists of defective proviral genomes with mutations that prevent production of HIV-1 virions. People with HIV (PWH), even with suppression of viremia, demonstrate comorbidities of the central nervous system, heart, gut, and general aging-associated inflammation. Previously, we identified a transcriptionally active element within the envelope gene (

Indexed as

HIV-1HIV InfectionsInterferonsMyeloid CellsProvirusesTranscription, GeneticChemokine CXCL10CytokinesDEAD Box Protein 58HumansInterleukin-8Promoter Regions, GeneticReceptors, ImmunologicChemokine CXCL10CytokinesDEAD Box Protein 58InterferonsInterleukin-8Receptors, ImmunologicRIGI protein, humandefective provirusesHIV-1inflammationtranscription

Identifiers

PMID42573264
PMCPMC13595952

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.