Evidence map›Paper›PMID 42573256›Full record

ArticlemBio2026

Identification of SKI-II as a host-protective immunomodulator against

Liyang Zhang, Kai Ye, Charilaos Dellis, Lewis Oscar Felix, Narchonai Ganesan, Biswajit Mishra, Aijun Zhang, Dale J Hamilton, Yizhi Jane Tao, Eleftherios Mylonakis

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liyang ZhangDepartment of Medicine, Houston Methodist Hospital, Houston, Texas, USA.ORCID 0009-0004-7042-0227
Kai YeDepartment of BioSciences, Rice University, Houston, Texas, USA.
Charilaos DellisDepartment of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Lewis Oscar FelixDepartment of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Narchonai GanesanDepartment of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Biswajit MishraDepartment of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Aijun ZhangDepartment of Medicine, Houston Methodist Hospital, Houston, Texas, USA.ORCID 0000-0003-1491-8528
Dale J HamiltonDepartment of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Yizhi Jane TaoDepartment of BioSciences, Rice University, Houston, Texas, USA.ORCID 0000-0002-0149-2241
Eleftherios MylonakisDepartment of Medicine, Houston Methodist Hospital, Houston, Texas, USA.ORCID 0000-0002-4624-0777

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4M
NIAID NIH HHS P01 AI083214
6 · The paper itself

Abstract

Antibiotic resistance threatens the effectiveness of conventional antimicrobial agents, underscoring the need for host-directed therapies that enhance immune defense. Here, we present a cross-species discovery pipeline that couples a

Indexed as

Caenorhabditis elegansImmunologic FactorsImmunomodulating AgentsStaphylococcal InfectionsStaphylococcus aureusAnimalsCaenorhabditis elegans ProteinsDNA-Binding ProteinsHost-Directed TherapyImmunity, InnateMacrophagesMiceNF-E2-Related Factor 2Oxidative StressRAW 264.7 CellsReactive Oxygen SpeciesCaenorhabditis elegans ProteinsDNA-Binding ProteinsImmunologic FactorsImmunomodulating AgentsNF-E2-Related Factor 2Reactive Oxygen Speciesskn-1 protein, C elegansTranscription FactorsValosin Containing ProteinCaenorhabditis elegansimmunomodulationNrf2SKI-IIStaphylococcus aureus

Identifiers

PMID42573256
PMCPMC13556259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.