Evidence map›Paper›PMID 42573249›Full record

ArticlemBio2026

Ecology of protection: probiotic biogeography and sepsis prevention in the neonatal intestine.

Sierra C Hansen, Christopher W Hamm, Jeffrey R Singer, Casey T Weaver, Michael J Gray

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sierra C HansenDepartment of Microbiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Christopher W HammDepartment of Microbiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jeffrey R SingerDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Casey T WeaverDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-2180-1793
Michael J GrayDepartment of Microbiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-7112-4188

Funding

Training Program in Cell, Molecular, and Developmental BiologyT32GM008111 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 1985 to 2022
$5.4M
Targeting the Intestinal Mucosa and Microbiome to Prevent Neonatal Late-onset SepsisR01AI164712 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRAY, MICHAEL JEFFREY, WEAVER, CASEY T · 2021 to 2025
$3.5M
National Institute of Allergy and Infectious Diseases R01AI164712NIAID NIH HHS R01 AI164712NIGMS NIH HHS T32 GM008111NIGMS NIH HHS T32GM008111
6 · The paper itself

Abstract

Neonatal infection is a leading cause of morbidity and mortality worldwide, particularly among preterm and low birth weight infants. Probiotic bacteria are widely used in peri- and postnatal care and can reduce neonatal intestinal dysbiosis. However, formulations and efficacy remain highly variable, highlighting a critical gap in our understanding of the mechanisms that drive successful interventions in this population. Furthermore, current studies on probiotic efficacy rely on indirect or relative measures of intestinal bacterial burden. Here, we directly mapped the biogeography of intestinal colonization and quantified the probiotic effects of

Indexed as

IntestinesKlebsiella InfectionsProbioticsSepsisAnimalsAnimals, NewbornDisease Models, AnimalDysbiosisEscherichia coliGastrointestinal MicrobiomeKlebsiella pneumoniaeMicemicrobial ecologyneonatal sepsisprobiotics

Identifiers

PMID42573249
PMCPMC13556230

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.