Profiling the aromatic amino acid metabolome in the human gut microbiota reveals

David Chun-Cheng Hsieh, Linhai Jiang, Mengzhao Xue, Niv Antonovsky, Sean F Brady

Abstract read

In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David Chun-Cheng HsiehLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA.ORCID 0009-0003-0806-9555

Linhai JiangLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA.

Mengzhao XueLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA.

Niv AntonovskyLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA.

Sean F BradyLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA.ORCID 0000-0001-5967-8586

Funding

Discovery of Antibiotics from Soil Microbiomes Using MetagenomicsR35GM122559 · NIGMS · ROCKEFELLER UNIVERSITY · PI SEAN F BRADY · 2017 to 2026

$4.7M

G. Harold and Leila Y. Mathers FoundationNIGMS NIH HHS R35 GM122559NIGMS NIH HHS R35GM122559

6 · The paper itself

Abstract

Owing to its compositional and chemical complexity, much of the gut microbiota metabolome remains poorly characterized. Aromatic amino acids (AAAs) have a history of being privileged substrates for the biosynthesis of diverse bioactive metabolites and thus represent a potentially rich source of bioactive molecules within the microbiota metabolome. In this study, we leveraged

Indexed as

Amino Acids, AromaticClostridioides difficileGastrointestinal MicrobiomeMetabolomeHumansLiquid Chromatography-Mass SpectrometryMetabolomicsPhenylacetatesAmino Acids, AromaticPhenylacetatesphenylacetic acidClostridioides difficilegut microbiomeisotope tracingmass spectrometrymetabolismmetabolomics

Identifiers

PMID42573234

DOI10.1128/msystems.00779-26

PMCPMC13595955

What OpenQuestion holds

Textmetadata

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.