Evidence map›Paper›PMID 42573122›Full record

ReviewClinical transplantation2026

A Review of Hemophagocytic Lymphohistiocytosis in Transplant-Focusing on the Heart.

Boaz Elad, Dor Lotan, Ilan Richter, Julia Baranowska, Daniel Oren, Farhana Latif, Kevin Clerkin, Gabriel Sayer, Nir Uriel

Abstract readReviewCase Reports
In one paragraph

Review in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Boaz EladColumbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York City, New York, USA.
Dor LotanColumbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York City, New York, USA.
Ilan RichterColumbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York City, New York, USA.
Julia BaranowskaColumbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York City, New York, USA.
Daniel OrenColumbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York City, New York, USA.
Farhana LatifColumbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York City, New York, USA.
Kevin ClerkinColumbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York City, New York, USA.
Gabriel SayerColumbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York City, New York, USA.
Nir UrielColumbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York City, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a complex and often difficult-to-diagnose disease that can be easily missed and is associated with high mortality. Transplantation serves as a predisposing factor, and the challenges in diagnosis and treatment are compounded in transplant patients. Although there are only a few documented cases of HLH in heart transplant (HT) recipients, the increasing prevalence of HT globally suggest that more cases are likely to emerge. In this review, we focus on HLH specifically in the context of HT. We present a unique and complex case report of HLH in a HT patient. Following this, we will review the disease in the general population and explore its impact on transplant patients. We will analyze existing data on HLH in HT recipients, clinical symptoms and signs, diagnosis and discuss various treatment strategies including currently recommended and alternative new approaches.

Indexed as

Heart TransplantationLymphohistiocytosis, HemophagocyticHumansPrognosiscytokine stormheart transplanthemophagocytic lymphohistiocytosis

Identifiers

PMID42573122
PMCPMC13455448

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.