SynthesisPhysiological reports2026
Melatonin as a protector against endocrine disruption across tissues: A systematic review.
Synthesis in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Protein sorting and proteostasis mechanisms in CFTR-related exocrine pancreas dysfunction: A systematic narrative review.Channels (Austin, Tex.) · 2026Pooled it
- Utero-placental calcium and magnesium ion channels: A systematic review of obstetric implications of their alterations.Channels (Austin, Tex.) · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocrine-disrupting chemicals (EDCs) are widespread environmental pollutants that interfere with hormonal homeostasis and contribute to multisystem toxicity. This systematic review aimed to synthesize available evidence on the protective effect of melatonin against EDC-induced toxicity across tissues. English language articles published between January 2000 and December 2025 were searched on PubMed, Web of Science, and Wiley Online. Eligible studies evaluated the protective or antagonistic effects of melatonin against EDC-induced toxicity in humans, mammals, or in vitro models. Data on study characteristics, EDC exposure, melatonin intervention, affected tissues, outcomes, and mechanisms were extracted, synthesized, and reported in accordance with the PRISMA 2020 guidelines. Sixty-one studies met the inclusion criteria. Melatonin exhibited protective effects against diverse EDCs, including bisphenols, phthalates, heavy metals, pesticides, and microplastics. The principal mechanisms identified were antioxidant and free-radical scavenging activity, modulation of hormone receptors, regulation of gene and protein expression, stabilization of endocrine axes, mitochondrial protection, and epigenetic modulation. These effects were observed across multiple organ systems, particularly the reproductive, neuroendocrine, cardiovascular, adrenal, and immune systems. Melatonin protects against EDC-induced multisystem toxicities by preserving endocrine signaling and coordinating cellular defense mechanisms across tissues, thereby holding therapeutic potential.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.