Evidence map›Paper›PMID 42573087›Full record

ArticleeLife2026

Translational reading frame predicts the pathogenicity of C-terminal frameshift deletions in MeCP2.

Jacky Guy, Elena Hein, Beatrice Alexander-Howden, Timur von Bock Und Polach, Tricia Mathieson, Benjamin P Kleinstiver, Huda Y Zoghbi, Adrian Bird

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jacky GuyUniversity of Edinburgh, Institute of Cell Biology, Michael Swann Building, Max Born Crescent, Edinburgh, United Kingdom.ORCID https://orcid.org/0000-0002-8440-5667
Elena HeinUniversity of Edinburgh, Institute of Cell Biology, Michael Swann Building, Max Born Crescent, Edinburgh, United Kingdom.
Beatrice Alexander-HowdenUniversity of Edinburgh, Institute of Cell Biology, Michael Swann Building, Max Born Crescent, Edinburgh, United Kingdom.ORCID https://orcid.org/0000-0001-7690-8478
Timur von Bock Und PolachUniversity of Edinburgh, Institute of Cell Biology, Michael Swann Building, Max Born Crescent, Edinburgh, United Kingdom.
Tricia MathiesonUniversity of Edinburgh, Institute of Cell Biology, Michael Swann Building, Max Born Crescent, Edinburgh, United Kingdom.
Benjamin P KleinstiverCenter for Genomic Medicine and Department of Pathology, Massachusetts General Hospital, Boston, United States.ORCID https://orcid.org/0000-0002-5469-0655
Huda Y ZoghbiDepartment of Molecular and Human Genetics and Neuroscience, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0002-0700-3349
Adrian BirdUniversity of Edinburgh, Institute of Cell Biology, Michael Swann Building, Max Born Crescent, Edinburgh, United Kingdom.ORCID https://orcid.org/0000-0002-8600-0372

Funding

Scalable Development of Custom Genome Editing TechnologiesDP2CA281401 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KLEINSTIVER, BENJAMIN PETER · 2022 to 2025
$2.5M
NCI NIH HHS DP2 CA281401NIH HHS DP2CA281401Rett Syndrome Research Trust 13669477_13669480Simons Initiative for the Developing Brain 13800235_1380239Wellcome 10.35802/222507Wellcome Trust
6 · The paper itself

Abstract

Mutations in the

Indexed as

Frameshift MutationMethyl-CpG-Binding Protein 2Rett SyndromeSequence DeletionAnimalsDisease Models, AnimalHumansMiceMECP2 protein, humanMethyl-CpG-Binding Protein 2adenine base editingframeshift mutationsgeneticsgenomicshumanMeCP2medicinemouseRett syndrome

Identifiers

PMID42573087
PMCPMC13456685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.