Evidence map›Paper›PMID 42572866›Full record

ArticleMediators of inflammation2026

The Expression Levels and Clinical Significance of CARDS TX, MyD88, and IL-8 of Children With Severe Mycoplasma pneumoniae Pneumonia.

Ding Zewen, Hou Jiapu, Sun Ruiyang, Jia Wanyu, Li Peng, Song Chunlan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ding ZewenHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450052, Henan, China, zzusah.com.ORCID https://orcid.org/0009-0007-0053-3092
Hou JiapuHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450052, Henan, China, zzusah.com.ORCID https://orcid.org/0009-0000-8649-1899
Sun RuiyangHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450052, Henan, China, zzusah.com.ORCID https://orcid.org/0009-0006-0514-4785
Jia WanyuHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450052, Henan, China, zzusah.com.ORCID https://orcid.org/0000-0001-6543-0501
Li PengHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450052, Henan, China, zzusah.com.ORCID https://orcid.org/0009-0002-9342-4875
Song ChunlanHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450052, Henan, China, zzusah.com.ORCID https://orcid.org/0000-0002-3750-7687

Funding

Henan Provincial Science and Technology Research Project 252102311119
6 · The paper itself

Abstract

objectiveTo investigate the expression levels of community-acquired respiratory distress syndrome toxin (CARDS TX), myeloid differentiation factor 88 (MyD88), and interleukin-8 (IL-8) in the bronchoalveolar lavage fluid (BALF) of children with severe Mycoplasma pneumoniae pneumonia (SMPP) and explore their clinical significance in the pathogenesis of SMPP.

methodsThis was a retrospective analysis of clinical data from 29 patients with SMPP and 12 patients with general Mycoplasma pneumoniae pneumonia (GMPP). Moreover, the expression levels of CARDS TX, MyD88, and IL-8 in the BALF of the two groups were detected and compared.

resultsThe expression levels of CARDS TX, MyD88, and IL-8 were positively correlated with SMPP (p  < 0.05). Univariate logistic regression analysis indicated that CARDS TX, MyD88, and IL-8 are potential risk factors for SMPP (p  < 0.05). The areas under the curve for the CARDS TX, MyD88, and IL-8 assays were 0.857, 0.730, and 0.799, respectively. The optimal cutoff values were 10.91 ng/mL, 2.21 ng/mL, and 120.52 pg/mL, respectively.

conclusionsElevated levels of CARDS TX, MyD88, and IL-8 in BALF all demonstrate diagnostic utility for children with SMPP, with CARDS TX exhibiting the highest diagnostic sensitivity. A CARDS TX concentration >10.91 ng/mL, a MyD88 concentration >2.21 ng/mL, and an IL-8 concentration >120.52 pg/mL are potential risk factors for SMPP.

Indexed as

Bacterial ProteinsBacterial ToxinsInterleukin-8Myeloid Differentiation Factor 88Pneumonia, MycoplasmaBronchoalveolar Lavage FluidChildChild, PreschoolFemaleHumansMaleMycoplasma pneumoniaeRetrospective StudiesBacterial ProteinsBacterial ToxinsCARDS toxin, Mycoplasma pneumoniaeInterleukin-8MYD88 protein, humanMyeloid Differentiation Factor 88bronchoalveolar lavage fluidCARDS TXIL-8MyD88severe Mycoplasma pneumoniae pneumonia

Identifiers

PMID42572866
PMCPMC13454890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.