ArticleCureus2026
Triple-Component Lung Carcinoma Diagnosed After Nondiagnostic EBUS: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Combined lung carcinomas containing both non-small cell and high-grade neuroendocrine components are rare and diagnostically challenging due to intratumoral heterogeneity. We report a 61-year-old never-smoking woman with pleuritic chest discomfort and chronic cough. Computed tomography (CT) and positron emission tomography (PET)/CT demonstrated a left upper-lobe pulmonary nodule with intensely FDG-avid hilar and mediastinal lymphadenopathy. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) of FDG-avid lymph nodes was nondiagnostic. Given persistent clinical and radiologic concern for malignancy, the patient underwent video-assisted thoracoscopic surgery (VATS) for definitive diagnosis. Pathology revealed a rare triple-component malignancy composed of adenocarcinoma, large-cell neuroendocrine carcinoma, and small-cell lung carcinoma, with metastatic neuroendocrine carcinoma involving mediastinal lymph nodes and pleura, consistent with stage IVA disease. The patient was subsequently treated with platinum-etoposide-based systemic therapy, with immunotherapy planned as part of her treatment course. This case highlights that nondiagnostic minimally invasive sampling does not exclude malignancy and underscores the importance of radiologic-pathologic concordance, awareness of sampling limitations, and timely escalation to additional tissue acquisition, including surgical biopsy when appropriate.
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