ArticleRomanian journal of ophthalmology
Personalized Orbital Fracture Repair: Enhancing 3D-Printed Titanium Mesh with Biomimetic 3D-Printed HAP-COL Frameworks.
Article in Romanian journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Objective: Orbital wall fractures require precise reconstruction to restore orbital volume and visual function, and bio-inert titanium implants benefit substantially from osteoconductive surface modifications. This study evaluated the biocompatibility and osteogenic potential of hydroxyapatite-collagen (HAP-COL) composites used in titanium implants intended for orbital fracture repair, comparing a sprayed HAP coating with a robocasting-deposited, 3D-printed HAP-COL layer. Methods: HAp-COL hybrid powder (HAp:COL mass ratio 4:1) was prepared by hydrothermal synthesis at 100 °C and 10 Results: Both samples showed dose- and time-dependent viability profiles within the acceptable limits of ISO 10993-5. Sample 1 viability ranged from 70.62% (stock) to 89.72% (1/8) at 24 h, and from 77.28% to 93.63% at 48 h. Sample 2 consistently outperformed Sample 1, with values from 80.61% to 91.28% at 24 h and from 83.35% to 96.47% at 48 h. Discussion: Both HAP-COL application techniques proved highly biocompatible and compliant with ISO 10993-5 non-cytotoxic safety limits. However, the 3D-printed robocast layer (Sample 2) consistently outperformed the sprayed coating, exhibiting superior osteoblast viability and proliferation. This demonstrates that a layered, biomimetic robocast architecture optimizes cell survival and successfully mitigates the bio-inert properties of standard titanium. Conclusions: The 3D-printed HAP-COL coating produced by robocasting exhibited superior biocompatibility and osteoconductive behavior compared with the sprayed alternative, supporting sustained osteoblast proliferation. HAP-COL robocast layers on titanium represent promising candidates for personalized orbital wall reconstruction, although in vivo validation remains necessary.
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