Evidence map›Paper›PMID 42572611›Full record

ArticleiScience2026

A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms.

Shimei Wang, Xudong Cui, Gang Yu, Xinwei Wan, Shinan Wei, Jia Yu, Sha Cheng, Dawei Zhang, Tomii Ayaka, Xiaoren Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shimei WangDepartment of Infectious Disease, The Fourth Hospital of Harbin Medical University, Harbin 150001, P.R. China.
Xudong CuiDepartment of Infectious Disease, The Fourth Hospital of Harbin Medical University, Harbin 150001, P.R. China.
Gang YuState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, P.R. China.
Xinwei WanState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, P.R. China.
Shinan WeiState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, P.R. China.
Jia YuState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, P.R. China.
Sha ChengState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, P.R. China.
Dawei ZhangInstitute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou 213001, P.R. China.
Tomii AyakaDepartment of Infectious Disease, The Fourth Hospital of Harbin Medical University, Harbin 150001, P.R. China.
Xiaoren WangDepartment of Infectious Disease, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China.
Wanru HanDepartment of Infectious Disease, The Fourth Hospital of Harbin Medical University, Harbin 150001, P.R. China.
Bixue XuState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, P.R. China.
Heng LuoState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, P.R. China.
Lei YuDepartment of Infectious Disease, The Fourth Hospital of Harbin Medical University, Harbin 150001, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) still has limitations such as tumor resistance, recurrence, and poor prognosis. Therefore, the development of anticancer drugs with mechanisms of action is of great significance for the treatment of HCC. In this study, we identified KZL-064, a 2-trifluoromethyl-4-aminoquinazoline derivative, which markedly inhibits HCC cell proliferation, migration, and invasion, induces apoptosis and G

Indexed as

apoptosisHDAC1hepatocellular carcinomahistone acetylationKZL-064trifluoromethyl quinazoline

Identifiers

PMID42572611
PMCPMC13453028

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.