Evidence map›Paper›PMID 42572610›Full record

SynthesisRomanian journal of ophthalmology

Endoscopic Endonasal Optic Nerve Decompression for Traumatic Optic Neuropathy: A Systematic Review.

Babak Ganjeifar, Seyed Reza Ahmadi Koupaei, Ali Moradi

Abstract readSystematic Review
In one paragraph

Synthesis in Romanian journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Babak GanjeifarDepartment of Neurosurgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Reza Ahmadi KoupaeiDepartment of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Ali MoradiClinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Traumatic optic neuropathy (TON) is an acute injury to the optic nerve caused by direct or indirect trauma, often resulting in vision loss. Endoscopic transsphenoidal optic nerve decompression (EOND) is a minimally invasive technique designed to relieve pressure on the optic nerve. This systematic review evaluates the efficacy, safety, and visual outcomes of EOND in patients with TON. Methods: A systematic search of PubMed, Scopus, and Google Scholar was conducted for articles published between 2014 and 2024. Keywords included "optic nerve decompression", "traumatic optic neuropathy", and "endoscopic optic nerve decompression". After screening 42 articles, 16 studies met the inclusion criteria and were analyzed. Results: All included studies used the endoscopic transsphenoidal approach. The mean visual recovery rate was 58.4%. All patients received postoperative corticosteroids. Study populations ranged from 11.7 to 68.1 years, including 24 females and 354 males. Postoperative complications were reported in 25% of studies, most commonly cerebrospinal fluid (CSF) leaks. Discussion: Our findings demonstrated that endoscopic endonasal optic nerve decompression (EOND) is a safe and effective option for traumatic optic neuropathy (TON) patients unresponsive to steroids, with a mean visual recovery rate of 58.4% and a low complication profile, most commonly CSF leaks. While EOND offers clear advantages over traditional approaches, including minimal invasiveness and excellent visualization, the heterogeneity of existing data and the limited number of high-quality studies underscore the need for standardized protocols and further prospective research to optimize patient selection and surgical timing. Conclusion: EOND is a safe and effective intervention for TON patients unresponsive to medical therapy, offering minimal scarring, improved visualization, and rapid recovery. However, the limited number of studies and the heterogeneity of data highlight the need for further high-quality research to optimize outcomes.

Indexed as

Decompression, SurgicalEndoscopyOptic NerveOptic Nerve InjuriesHumansVisual AcuityCT = Computed tomographyendoscopic surgeryEOND = Endoscopic optic nerve decompressionminimally invasiveMRI = Magnetic resonance imagingOND = Optic nerve decompressionoptic nerve decompressionoptic nerve injuryRAPD = Relative afferent pupillary defectRGC = Retinal ganglion cellsTON = Traumatic optic neuropathytranssphenoidal surgerytraumatic optic neuropathyVA = Visual acuityvisual recovery

Identifiers

PMID42572610
PMCPMC13453100

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.