Evidence map›Paper›PMID 42572605›Full record

ArticleiScience2026

Loss of YY1 in Purkinje cells triggers cerebellar ataxia via Wnt10b-mediated impairment of dendrite development.

Ying Lam Lui, Xiaonan Dong, Thomas Chun Ning Leung, Tsz Ho Li, Ting Fung Chan, Kin Ming Kwan

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying Lam LuiSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Xiaonan DongSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Thomas Chun Ning LeungSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Tsz Ho LiSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Ting Fung ChanSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Kin Ming KwanSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cerebellum relies on Purkinje cells (PCs) to coordinate motor functions and maintain neural circuitry. Impaired PC dendritogenesis is linked to neurological disorders, yet intrinsic molecular mechanisms remain unclear. We demonstrate that postnatal deletion of Yin Yang 1 (

Indexed as

cerebellar ataxiadendritogenesispurkinje cellWnt10bYY1

Identifiers

PMID42572605
PMCPMC13453040

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.