Evidence map›Paper›PMID 42572591›Full record

ArticleUrology case reports2026

First reported stevia-containing human urinary calculi.

Sara L Best, John R Asplin, Natalia Gromadzka, Benjamin C Owen, Yongbo Zhang, Valentinas Gruzdys

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sara L BestDepartment of Urology, University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA.
John R AsplinLitholink, Laboratory Corporation of America, Itasca, IL, USA.
Natalia GromadzkaLitholink, Laboratory Corporation of America, Itasca, IL, USA.
Benjamin C OwenDepartment of Chemistry, Integrated Molecular Structure Education and Research Center, Northwestern University, Evanston, IL, USA.
Yongbo ZhangDepartment of Chemistry, Integrated Molecular Structure Education and Research Center, Northwestern University, Evanston, IL, USA.
Valentinas GruzdysLitholink, Laboratory Corporation of America, Itasca, IL, USA.

Funding

STRUCTURAL BIOL RES: LUNG SURFACTANT PROTEINS, DISTRESSS10RR019071 · NCRR · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2005 to 2005
$272k
NCRR NIH HHS S10 RR019071
6 · The paper itself

Abstract

While most kidney stones are made of typical substances like calcium oxalate, patients with uncommon metabolic disorders or exposures/ingestions can crystallize rare materials in their urinary tracts, leading to unusual stone compositions. Six stones in 5 individuals were evaluated when their composition did not match known lithogenic substances. We report the first ever identified human urinary calculi composed of steviol, a metabolite of the no-calorie sweetener, stevia.

Indexed as

NephrolithiasisSteviaSupplementsUrinary calculi

Identifiers

PMID42572591
PMCPMC13453014

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.