ArticleInternational journal of pharmaceutics: X2026
Implantable starch-based extrudates for controlled release of corticosteroids.
Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Effective management of postoperative pain remains a major clinical challenge, driving the development of biodegradable implantable systems for localized drug delivery. Local control of postoperative inflammation plays an important role in pain management and represents a promising strategy for improving postoperative recovery. Starch-based implantable systems have recently emerged as promising biodegradable platforms for this purpose. Although polyester-based implants such as PLA and PLGA are widely used for sustained drug release, they present limitations, including poor mechanical behavior, delayed drug release, and the formation of acidic microenvironments during polymer degradation. In contrast, starch-based matrices represent an attractive alternative due to their intrinsic hydrophilicity, rapid hydration, and degradation into non-acidic products. This study aimed to characterize starch-based extrudates containing dexamethasone derivatives for potential application in postoperative pain and inflammation. Flexible cylindrical extrudates with nominal diameters of 600 μm and 1000 μm were produced using approved pharmaceutical excipients. Hydration studies revealed rapid water uptake within the first hour of incubation and swelling of approximately 30% without structural disintegration. Cyclodextrin-containing extrudates exhibited early matrix erosion within the first 24 h due to cyclodextrin dissolution, as confirmed by
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