Evidence map›Paper›PMID 42572582›Full record

ArticleiScience2026

Astrovirus infection dysregulates goblet cell-associated antigen passages.

Jacob Gulman, Nicole Heredia-Osuna, Mané Ohanyan, Alejandro Poot, Cristina Vargas, Victoria Auerbuch, Keely G McDonald, Rodney D Newberry, Valerie Cortez

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacob GulmanDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA.
Nicole Heredia-OsunaDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA.
Mané OhanyanDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, USA.
Alejandro PootDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA.
Cristina VargasDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, USA.
Victoria AuerbuchDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, USA.
Keely G McDonaldDivision of Gastroenterology, Department of Medicine, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA.
Rodney D NewberryDivision of Gastroenterology, Department of Medicine, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA.
Valerie CortezDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA.

Funding

The interplay between early-life enteric virus infection and the development of oral toleranceR21DK139534 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CORTEZ, VALERIE · 2025 to 2025
$573k
Astrovirus modulation of gut immunity via goblet cellsK22AI156116 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CORTEZ, VALERIE · 2021 to 2022
$312k
NIAID NIH HHS K22 AI156116NIDDK NIH HHS R21 DK139534
6 · The paper itself

Abstract

Astroviruses are a major cause of pediatric diarrhea worldwide. Goblet cells are a primary target for astrovirus infection. In addition to secreting mucus, goblet cells facilitate oral tolerance through the formation of goblet cell-associated antigen passages (GAPs). Previous work showed that GAPs close in response to

Indexed as

astrovirusco-infectionenteric virusepidermal growth factor receptorgoblet cellgoblet cell-associated antigen passageSalmonella

Identifiers

PMID42572582
PMCPMC13453033

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.