Evidence map›Paper›PMID 42572553›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

Analysis of causes and outcomes of principal secondary thrombotic microangiopathy: a 9-year cohort study from a tertiary pediatric center in China.

Dan Wu, Jie Zheng, Jun Yang, Bin Wang, Guanghua Zhu, Zhi Chen, Qiang Sun, Nan Zhou, Zhenping Chen, Yanhui Luo and 14 more

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Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Causes and outcomes of pediatric thrombotic microangiopathy.Research and practice in thrombosis and haemostasis · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Dan WuDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Jie ZhengDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Jun YangDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Bin WangDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Guanghua ZhuDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Zhi ChenDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Qiang SunDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Nan ZhouDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Zhenping ChenClinical Laboratory, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Yanhui LuoDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Wei YangDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Xiaoyu TianDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Hejia ZhangDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Xue LiuDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Lei LeiDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Na TianDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Kaige ZhangDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Li FangDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Lan MiDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Ang WeiDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Ying LiangDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Maoquan QinDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Xiaorong LiuDepartment of Nephrology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Chenguang JiaDepartment of Stem Cell Transplantation, Hematology Center, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Few large-scale cohort studies have reviewed consecutive cases of thrombotic microangiopathy (TMA), especially in children. Objectives: The aim of our study was to evaluate causes and outcomes of TMA at a tertiary pediatric center in China over a 9-year period. Methods: We retrospectively analyzed consecutive pediatric TMA patients admitted to Beijing Children's Hospital from December 2015 to January 2025. The primary endpoint was death or progression to kidney failure. Multivariable Cox regression identified independent predictors of this composite endpoint. Results: We retrospectively analyzed 303 consecutive pediatric patients with a first episode of TMA. Secondary TMA was the most common type ( Conclusion: This study shows that secondary TMA is the predominant form of pediatric TMA. Secondary TMA, heart failure/shock, and the requirement for mechanical ventilation were identified as independent risk factors for death or kidney failure in children.

Indexed as

Thrombotic MicroangiopathiesAdolescentAtypical Hemolytic Uremic SyndromeChildChild, PreschoolChinaDisease ProgressionFemaleHematopoietic Stem Cell TransplantationHemolytic-Uremic SyndromeHospitals, PediatricHumansInfantMaleProportional Hazards ModelsPurpura, Thrombotic Thrombocytopenicchildcohort studyhemolytic-uremic syndromethrombotic microangiopathythrombotic thrombocytopenic purpura

Identifiers

PMID42572553
PMCPMC13452974

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