Evidence map›Paper›PMID 42572552›Full record

ArticleMolecular imaging

Multiparametric CEST MRI for Time-Associated Characterization of Acute Ischemic Stroke: NOE (-3.5 ppm) Signal as a Potential Imaging Biomarker.

Zitong Min, Yupeng Wu, Hongjie Huang, Qifan Pang, Hui Xu, Mingyang Peng, Huiyou Chen, Xindao Yin, Jianqi Li, Liang Jiang

Abstract read
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In one paragraph

Article in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zitong MinDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yupeng WuShanghai Key Laboratory of Magnetic Resonance, School of Physics, East China Normal University, Shanghai, China.
Hongjie HuangDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Qifan PangShanghai Key Laboratory of Magnetic Resonance, School of Physics, East China Normal University, Shanghai, China.
Hui XuDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Mingyang PengDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Huiyou ChenDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xindao YinDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Jianqi LiShanghai Key Laboratory of Magnetic Resonance, School of Physics, East China Normal University, Shanghai, China.
Liang JiangDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0001-6111-7948

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated time-dependent group-level changes in chemical exchange saturation transfer (CEST) signals in a mouse model and explored utility in identifying stroke onset time. Multiparametric magnetic resonance imaging (diffusion weighted imaging, arterial spin labeling, and CEST) was conducted on 12 normal and 26 ischemic mice. Imaging findings were validated by immunohistochemical analysis. CEST parameters in infarct and penumbra were compared between strokes within 4.5 h and over 4.5 h. Correlations, regression, and receiver operating characteristic curves evaluated performance. Infarct guanidine, magnetization transfer (MT), nuclear Overhauser enhancement (NOE) (-3.5 ppm), and NOE (-1.6 ppm) significantly differed between groups and associated with onset time (

Indexed as

BiomarkersBrain IschemiaIschemic StrokeMagnetic Resonance ImagingMultiparametric Magnetic Resonance ImagingAnimalsMaleMiceMice, Inbred C57BLROC CurveTime FactorsBiomarkersdiagnosisischemic strokelipidsmagnetic resonance imagingonset time

Identifiers

PMID42572552
PMCPMC13452940

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.