Evidence map›Paper›PMID 42572539›Full record

ArticleJournal of diabetes and metabolic disorders2026

Effects of time-restricted feeding and high-intensity interval training on thermogenesis-related protein abundance in white adipose tissue of diabetic rats.

Ahmad Reza Moein, Mohammad Javad Pourvaghar, Fatemeh Kazeminasab, Maryam Baharlooie, Reza Bagheri, Darryn Willoughby, Fred Dutheil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes and metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmad Reza MoeinDepartment of Physical Education and Sports Science, Faculty of Humanities, University of Kashan, Kashan, Iran.
Mohammad Javad PourvagharDepartment of Physical Education and Sports Science, Faculty of Humanities, University of Kashan, Kashan, Iran.
Fatemeh KazeminasabDepartment of Physical Education and Sports Science, Faculty of Humanities, University of Kashan, Kashan, Iran.
Maryam BaharlooieDepartment of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Reza BagheriDepartment of Exercise Physiology, University of Isfahan, Isfahan, Iran.
Darryn WilloughbyDepartment of Education, Innovation, and Technology, Baylor College of Medicine-School of Medicine, Temple, TX USA.
Fred DutheilLaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, Université Clermont Auvergne, CNRS, University Hospital of Clermont-Ferrand, Preventive and Occupational Medicine, Witty Fit, Clermont-Ferrand, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study evaluated the independent and combined effects of time-restricted feeding (TRF) and high-intensity interval training (HIIT) on thermogenesis-related protein abundance in white adipose tissue (WAT) of diabetic rats. Methods: Forty male Wistar rats were divided into normal and diabetic groups (high-fat diet plus streptozotocin). Diabetic rats were randomly allocated into four subgroups: control, TRF, HIIT, and combined TRF+HIIT groups. After a 10-week intervention, the protein abundance of AMPK, PGC-1α, and UCP1 was assessed in WAT. Fasting glucose, insulin, HOMA-IR, and adipocyte cross-sectional area were also measured. Results: Diabetes induction increased blood glucose and adipocyte cross-sectional area while reducing thermogenic proteins. Both TRF and HIIT significantly reduced fasting glucose, HOMA-IR, insulin, and adipocyte cross-sectional area, with no significant difference between the two. AMPK levels increased significantly with TRF ( Conclusion: TRF and HIIT were associated with improved glycemic outcomes and reduced adipocyte cross-sectional area. They were also associated with changes in thermogenesis-related protein abundance in diabetic WAT, with a statistically significant but context-dependent TRF × HIIT interaction observed for UCP1. These findings provide preliminary protein-level evidence of metabolic adaptations in WAT; however, their functional significance remains to be established. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-026-02032-0.

Indexed as

High‑intensity interval trainingThermogenesisTime‑restricted feedingType 2 diabetes mellitusWhite adipose tissue

Identifiers

PMID42572539
PMCPMC13452795

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.