In one paragraphArticle in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Poomipat ThaitongsukDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.
Adriana C C GirardiDepartamento de Cardiopneumologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0003-3715-6917 Ashley MorrowDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.
Kisho MiyasakoDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0009-0004-1280-8135 Janelle Siliezar-DoyleDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0002-7723-0299 Rose Z HillDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0001-9558-6400 Loren W RunnelsDepartment of Pharmacology, Rutgers-Robert Wood Johnson Medical School, Piscataway, New Jersey, United States.
Jeroen H F de BaaijDepartment of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-2372-8486 Joost G J HoenderopDepartment of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-1816-8544 James A McCormickDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0003-4000-6653 Funding
Oregon Clinical and Translational Research Institute TL1 ProgramTL1TR002371 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLISON Deborah FRYER, JESSINA C MCGREGOR · 2017 to 2026
$6.2MMagnesium handling by the distal nephronR01DK132066 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JAMES A MCCORMICK · 2023 to 2026
$1.3MFunctional interrogation of sensory neurons in inflammationR00NS133478 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Rose Z Hill · 2025 to 2026
$495kRole of CNNM2 in Neuronal Mg2+ Homeostasis, Function and DevelopmentR21NS140895 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI JAMES H. MILLONIG, LOREN W RUNNELS · 2025 to 2026
$432kFunctional interrogation of sensory neurons in inflammationK99NS133478 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI HILL, ROSE Z · 2023 to 2024
$240kAmerican Heart Association (AHA) 23EIA1037600Collins Medical Trust (CMT)EC | European Research Council (ERC) 101040682HHS | NIH | National Center for Advancing Translational Sciences (NCATS) TL1TR002371HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK132066HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS133478HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R21NS140895NCATS NIH HHS TL1 TR002371Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) 09150172110040Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) OCENW.M.21.022NIDDK NIH HHS R01 DK132066NINDS NIH HHS K99 NS133478NINDS NIH HHS R00 NS133478NINDS NIH HHS R21 NS140895Sao Paolo State Research Foundation 2024/14474-9Sao Paolo State Research Foundation FAPESP2021/14534-3
6 · The paper itselfAbstract
The renal distal convoluted tubule (DCT) plays a key role in magnesium homeostasis, with genetic and drug-induced causes of hypomagnesemia affecting this segment. The importance of the renal transient receptor potential melastatin (TRPM) 6 channel subunit of the TRPM6/7 magnesium channel in magnesium homeostasis is unclear due to discrepant findings in knockout mice. Furthermore, the apical voltage-gated potassium channel subtype 1.1 (Kv1.1) has been proposed to drive magnesium entry through TRPM6/7 along DCT, with limited experimental evidence. To clarify the roles of TRPM6 and Kv1.1, we generated mice with inducible DCT-specific TRPM6 knockout (DCT-TRPM6 KO) or renal tubule Kv1.1 knockout (tubule-Kv1.1 KO). Using a newly generated antibody, we found that TRPM6 expression is restricted to early DCT (DCT1), consistent with single-cell transcriptomic data. DCT-TRPM6 KO displayed lower plasma [Mg
Indexed as
Kidney Tubules, DistalKv1.1 Potassium ChannelMagnesiumTRPM Cation ChannelsAnimalsHomeostasisMaleMiceMice, Inbred C57BLMice, KnockoutKv1.1 Potassium ChannelMagnesiumTrpm6 protein, mouseTRPM Cation ChannelsKCNA1kidneymagnesiumTRPM6
Identifiers
PMID42572410
PMCPMC13543215
What OpenQuestion holds
Textmetadata
Read underepoch 390