Evidence map›Paper›PMID 42572081›Full record

ArticleLasers in medical science2026

Combination of Bauhinia monandra extract and laser acupuncture reduces carrageenan-induced paw edema.

Allyne Aparecida Dias da Silva Castro, Rogério Carvalho da Costa Junior, Eloisa Acerbi Laurindo, Lorena Campos Soares, Tatyane Matos Fernandes, Nerilson Marques Lima, Diego Mendes Xavier, Murilo Xavier Oliveira, Sandra Bertelli Ribeiro Castro, Caio César de Souza Alves and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Allyne Aparecida Dias da Silva CastroUniversidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.
Rogério Carvalho da Costa JuniorUniversidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.
Eloisa Acerbi LaurindoFederal University of Lavras, Lavras, Brazil.
Lorena Campos SoaresFederal University of Lavras, Lavras, Brazil.
Tatyane Matos FernandesFederal University of Lavras, Lavras, Brazil.
Nerilson Marques LimaFederal University of Lavras, Lavras, Brazil.
Diego Mendes XavierUniversidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil. diegomendesxav@gmail.com.
Murilo Xavier OliveiraUniversidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.
Sandra Bertelli Ribeiro CastroUniversidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.
Caio César de Souza AlvesUniversidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.
Alessandra de Paula CarliUniversidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the anti-inflammatory effect of the ethanolic extract of Bauhinia monandra Kurz (EEB) alone and combined with laser acupuncture (LA) in a carrageenan-induced paw edema model.

methodsEEB was characterized using HPLC-HRMS and tested for cell viability and nitric oxide (NO) production in RAW 264.7 and J774A.1 macrophages. In vivo, female BALB/c mice with paw edema were treated with EEB (100 or 200 mg/kg) alone, combined with LA (808 nm, 120 mW, 3 J, 25 s) at acupoints ST36 and SP6, or local laser. Paw edema was measured up to 4 h post-induction, and cytokine levels (IL-1$\beta$ and IL-6) were quantified.

resultsEEB showed no cytotoxicity and significantly reduced NO production in vitro. Phytochemical analysis revealed a predominance of phenolic compounds, including flavonoids. In vivo, both EEB and LA significantly reduced edema. Notably, the EEB200 + LA group produced reductions in paw edema and pro-inflammatory cytokines comparable to the dexamethasone group.

conclusionEEB demonstrated anti-inflammatory activity both in vitro and in vivo. Combining EEB (200 mg/kg) with LA yielded a more consistent anti-inflammatory response than either treatment alone, particularly in reducing edema and pro-inflammatory cytokines. These findings support further investigation, though larger sample sizes and chronic models are required before clinical claims.

Indexed as

Acupuncture TherapyAnti-Inflammatory AgentsBauhiniaEdemaLow-Level Light TherapyPlant ExtractsAnimalsCarrageenanCombined Modality TherapyDisease Models, AnimalFemaleMiceMice, Inbred BALB CNitric OxideRAW 264.7 CellsAnti-Inflammatory AgentsCarrageenanNitric OxidePlant ExtractsAnti-inflammatory agentsBauhinia monandraLaser acupuncturePhotobiomodulationPlant extracts

Identifiers

PMID42572081
PMCPMC13453983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.