Evidence map›Paper›PMID 42572063›Full record

ArticleActa neurologica Belgica2026

Cervical artery dissection after upper respiratory infection: clinical features and prognosis.

Sara D B Rosa, Mafalda Soares, Ana Paiva Nunes, Liqi Shu, Eileen Wu, Nils Henninger, Jayachandra Muppa, Mirjam R Heldner, Kateryna Antonenko, Setareh Omran and 21 more

Abstract read
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In one paragraph

Article in Acta neurologica Belgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Sara D B RosaNeuroradiology Department, Department of Neurosciences, ULS de São José, Lisbon, Portugal.ORCID http://orcid.org/0000-0001-9585-1446
Mafalda SoaresNeurology Department, Department of Neurosciences, ULS de São José, Lisbon, Portugal.
Ana Paiva NunesStroke Center, Department of Neurosciences, ULS de São José, Lisbon, Portugal.
Liqi ShuDepartment of Neurology, Brown Medical School, The Warren Alpert Medical School of Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0002-9784-8475
Eileen WuBrown University, Providence, RI, USA.
Nils HenningerDepartment of Neurology, University of Massachusetts, Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-3883-5623
Jayachandra MuppaDepartment of Neurology, University of Massachusetts, Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-3659-5862
Mirjam R HeldnerDepartment of Neurology, Inselspital, University Hospital and University of Bern, Bern, Switzerland.
Kateryna AntonenkoDepartment of Neurology, Inselspital, University Hospital and University of Bern, Bern, Switzerland.
Setareh OmranDepartment of Neurology, University of Colorado, Denver, CO, USA.
Ahmad NehmeService de Neurologie, Université Caen Normandie, CHU Caen Normandie, Caen, 14000, France.
Aaron RothsteinDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Ossama KhazaalDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Issa MetanisDepartment of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Ronen R LekerDepartment of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Malik GhannamDepartment of Neurology, University of Iowa, Iowa City, IA, USA.
Bastien RiouxCenter for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Michele RomoliNeurology and Stroke Unit, Department of Neuroscience, Bufalini Hospital, Cesena, Italy.
Marialuisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Rosario PascarellaNeuroradiology Unit, Ospedale Santa Maria della Misericordia, Polesana, Rovigo, AULSS5, Italy.
Wayneho KamComprehensive Stroke Center, University of North Carolina Health Rex, Raleigh, NC, USA.
Brian Mac GroryDepartment of Neurology, Duke University, Durham, NC, USA.
Faddi VelezDepartment of Neurology, University of Oklahoma, Norman, OK, USA.
Mary PenckoferDepartment of Neurology, Cooper University, Camden, NJ, USA.
James SieglerDepartment of Neurology, Cooper University, Camden, NJ, USA.
Adeel S ZubairDepartment of Neurology, Yale New Haven Hospital, New Haven, CT, USA.
João Pedro MartoDepartment of Neurology, Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.
Danna KrupkaDepartment of Neurology, Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.
Marwa ElnazairDepartment of Neurology, University of Louisville, Louisville, KY, USA.
Shadi Yaghi *Department of Neurology, Brown Medical School, The Warren Alpert Medical School of Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0003-0031-1004
Diana Aguiar de Sousa *Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal. dianaaguiardesousa@medicina.ulisboa.pt.ORCID http://orcid.org/0000-0002-6702-7924

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrior studies have suggested an association between cervical artery dissection (CAD) and upper respiratory tract infection, although evidence remains scarce. We aimed to compare the clinical features and outcomes of CAD with and without history of upper respiratory infection.

methodsWe conducted a secondary analysis of a multicenter, international, retrospective study including adult patients diagnosed with spontaneous CAD between January 2015 and June 2022. History of recent upper respiratory tract infection (HURI) was defined as symptoms of cough, fever, sneezing and throat soreness (at least two) within the 30 days preceding CAD diagnosis, as documented in patient medical records. Baseline characteristics and outcomes were compared between patients with and without HURI.

resultsAmong 4,023 patients with CAD, 251 (6.2%) had HURI. Multi-vessel involvement was nearly twice as frequent in this group (19.1% vs. 10.5%, p < 0.001). In multivariable analyses, HURI was associated with lower rates of occlusive dissection (30.1% vs. 35.9%, adjusted OR [95% CI]: 0.76 [0.57-1.00]) and reduced odds of presenting with ischemic stroke symptoms (55.9% vs. 65.7%, aOR [95% CI]: 0.60 [0.46-0.79]) or hemorrhagic transformation (1.6% vs. 4.9%, p = 0.02). At day 90, patients with HURI were more likely to achieve favorable functional outcome (mRS ≤ 2 93.0% vs. 85.2%, aOR [95% CI]: 2.12 [1.10-4.11]). No significant differences were found in mortality or CAD recurrence between groups.

conclusionsOur findings suggest that CAD preceded by respiratory infection is associated with milder clinical presentation with better functional outcome, despite more frequent multivessel involvement.

Indexed as

Cervical Artery DissectionMultivessel DissectionPost-infectiousPost-infectious CADRespiratory InfectionStroke

Identifiers

PMID42572063

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