Evidence map›Paper›PMID 42571637›Full record

ArticleChembiochem : a European journal of chemical biology2026

Identification of Siderophores With Unexpected Antibacterial Properties From Actinoplanes teichomyceticus.

Abiodun S Oyedele, Somnath Jana, KyuOk Jeon, Navin Vazrala, Donald F Stec, Kwangho Kim, Gary A Sulikowski, Allison S Walker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abiodun S OyedeleDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-9528-5288
Somnath JanaVanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-2830-9451
KyuOk JeonVanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA.
Navin VazralaDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
Donald F StecDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Kwangho KimVanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA.
Gary A SulikowskiDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Allison S WalkerDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-5666-7232

Funding

Machine learning approaches for the discovery, repurposing, and optimization of natural products with therapeutic potential - Supplement to support grad training of Adrian RussR35GM146987 · NIGMS · VANDERBILT UNIVERSITY · PI Allison Sara Walker · 2022 to 2026
$2.4M
NIGMS NIH HHS R35GM146987
6 · The paper itself

Abstract

Actinoplanes teichomyceticus is a well-established producer of bioactive secondary metabolites, including the glycopeptide antibiotic teicoplanin. Although its antibiotic biosynthetic capacity has been extensively investigated, its siderophore diversity and any additional biological functions of these iron-chelating metabolites remain comparatively underexplored. We identified a reproducibly bioactive, teicoplanin-independent fraction that inhibited Bacillus spizizenii. Molecular networking applied to this fraction identified hydroxamate ferrioxamine and desferrioxamine-type siderophores as the dominant metabolites, including acylated analogs detected as Al

Indexed as

ActinoplanesAnti-Bacterial AgentsSiderophoresBacillusDeferoxamineEscherichia coliMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsDeferoxamineSiderophoresActinoplanes teichomyceticusantibioticsBacillus spizizeniiChrome azurol Sgenome miningliquid chromatography‐tandem mass spectrometrysiderophores

Identifiers

PMID42571637
PMCPMC13453071

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.