Evidence map›Paper›PMID 42571627›Full record

ArticleChemistry & biodiversity2026

Synthetic Sinapates: Antifungal, Molecular Docking, and ADMET Studies.

Fernando Emanuel de Sousa Ferreira, Jeremias Justo Emídio, Ézio Raul Alves de Sá, Rômulo Oliveira Barros, Paula Lima Nogueira, Ricardo Martins Ramos, Ricardo Dias de Castro, Damião Pergentino de Sousa

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fernando Emanuel de Sousa FerreiraLaboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
Jeremias Justo EmídioLaboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
Ézio Raul Alves de SáLaPeSI-Information Systems Research Laboratory, Department of Information, Environment, Health and Food Production, Federal Institute of Piauí, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0002-6340-7380
Rômulo Oliveira BarrosLaPeSI-Information Systems Research Laboratory, Department of Information, Environment, Health and Food Production, Federal Institute of Piauí, Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0002-0000-033X
Paula Lima NogueiraLaboratory of Experimental Pharmacology and Cell Culture, Department of Clinical and Social Dentistry, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
Ricardo Martins RamosLaboratory of Experimental Pharmacology and Cell Culture, Department of Clinical and Social Dentistry, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.ORCID https://orcid.org/0000-0003-2016-3344
Ricardo Dias de CastroLaboratory of Experimental Pharmacology and Cell Culture, Department of Clinical and Social Dentistry, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.ORCID https://orcid.org/0000-0001-7986-7376
Damião Pergentino de SousaLaboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.ORCID https://orcid.org/0000-0002-7180-4896

Funding

CAPESCNPq
6 · The paper itself

Abstract

The increasing incidence of diseases resulting from fungal infections is due to the high morbidity and mortality associated with these microorganisms. Sinapic acid is a plant-derived phenolic compound with antifungal activity. Therefore, in this study, a collection of eleven sinapates (1-11) was prepared and the antifungal activity of these compounds was evaluated against Candida albicans and Candida tropicalis. Compounds 4, 5, and 8 showed good antifungal activity. Compound 4 presented minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of 62.5 µg/mL against C. albicans and 15.62 µg/mL against C. tropicalis. Compound 5 showed MIC and MFC values of 7.81 µg/mL against both strains, while compound 8 presented MIC and MFC values of 15.62 µg/mL against C. albicans and 62.5 µg/mL against C. tropicalis. The ratio MFC/MIC<4 showed that the compounds exerted a fungicidal effect. The ergosterol assay suggests that the mechanism of action occurs via the plasma membrane. The silico study, including ADMET predictions, suggested that most of the compounds have satisfactory pharmacokinetic and toxicological properties. Therefore, sinapates appear to be promising prototypes for the development of new anti-Candida drug candidates.

Indexed as

Antifungal AgentsCandida albicansCandida tropicalisCoumaric AcidsMolecular Docking SimulationMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAntifungal AgentsCoumaric Acidssinapinic acidCandidachemoinformaticsfungicidesnatural productssinapic acid

Identifiers

PMID42571627
PMCPMC13453077

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.